Evidence map›Paper›PMID 35978426›Full record

ArticleWorld journal of surgical oncology2022

Expression profile and prognostic value of CXCR family members in head and neck squamous cell carcinoma.

Yiming Shen, Chongchang Zhou, Yujie Cao, Qun Li, Hongxia Deng, Shanshan Gu, Yidong Wu, Zhisen Shen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yiming Shen *Department of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Chongchang Zhou *Department of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Yujie CaoDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Qun LiDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Hongxia DengDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Shanshan GuDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Yidong WuDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China.
Zhisen ShenDepartment of Otolaryngology, Head and Neck Surgery, The Affiliated Lihuili Hospital, Ningbo University, Ningbo, China. szs7216@163.com.
Ningbo Medical Center Lihuili Hospital · CNNingbo University · CN

Funding

Medical and Health Research Project of Zhejiang Province 2019ZD018;2021KY307Ningbo Health Branding Subject Fund No.PPXK2018-02Ningbo "Technology Innovation 2025" Major Special Project 2020Z097;2018B10015Zhejiang Provincial Natural Science Foundation of China LY19H160014;LQ21H130001
6 · The paper itself

Abstract

backgroundCXC chemokine receptor gene family consists of seven well-established members which are broadly involved in biological functions of various cancers. Currently, limited studies have shed light on the expression profile of CXCR family members (CXCRs), as well as their prognostic value, in head and neck squamous cells carcinoma (HNSCC).

methodsThe data for this study were retrieved from the Cancer Genome Atlas database and other publicly available databases, including gene expression, methylation profiles, clinical information, immunological features, and prognoses. The expression pattern and prognostic values of CXCRs were identified, and the potential mechanism underlying CXCRs function in HNSCC was investigated by gene set enrichment analysis (GSEA).

resultsCXCRs were differentially expressed in HNSCC. As shown by Kaplan-Meier analysis, high CXCR3-6 expression was significantly associated with better prognostic outcomes of HNSCC patients, including overall survival and progression-free survival. According to the results of univariate and multivariate Cox proportional risk regression analysis, it was demonstrated that upregulation of CXCR3-6 was an independent factor for better prognosis, while the two other clinical features, age and stage, were factors for worse prognosis. A significant positive correlation between CXCR3-6 and tumor-infiltrated immune cells was revealed by results from Tumor Immune Estimation Resource and CIBERSORT analysis database. The main involvement of CXCRs in immune and inflammatory responses was further confirmed by GSEA.

conclusionsOverall, this study provided a rationale for targeting CXCRs as a promising therapeutic strategy of HNSCC.

Indexed as

Head and Neck NeoplasmsReceptors, CXCRBiomarkers, TumorGene Expression Regulation, NeoplasticHumansKaplan-Meier EstimatePrognosisSquamous Cell Carcinoma of Head and NeckBiomarkers, TumorReceptors, CXCRCXC chemokine receptor gene familyHead and neck squamous cell carcinomaPrognosisSurvivalThe Cancer Genome Atlas

Identifiers

PMID35978426
PMCPMC9382762
OpenAlexW4292099741

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.