Evidence map›Paper›PMID 35978400›Full record

SynthesisAnnals of clinical microbiology and antimicrobials2022

Antibacterial activity of recently approved antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) strains: A systematic review and meta-analysis.

Fei Liu, Sajad Rajabi, Chunhua Shi, Ghazale Afifirad, Nazanin Omidi, Ebrahim Kouhsari, Saeed Khoshnood, Khalil Azizian

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Annals of clinical microbiology and antimicrobials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Identification of genetic mutations conferring tedizolid resistance in MRSA mutants.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2025
    Article
  6. Article
  7. MRSA: the enduring foe.Infection prevention in practice · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Modulation of the Gut Microbiota by the Plantaricin-ProducingInternational journal of molecular sciences · 2023
    Article
  16. Review
  17. Article
  18. International journal of molecular sciences · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Fei LiuDepartment of Biomedical Engineering, Changzhi Medical College, Changzhi, 046013, Shanxi, China.
Sajad RajabiInternational Medical Campus, Iran University of Medical Sciences, Tehran, Iran.
Chunhua ShiDepartment of Biomedical Engineering, Changzhi Medical College, Changzhi, 046013, Shanxi, China. liufei126@163.com.
Ghazale AfifiradDepartment of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nazanin OmidiClinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Ebrahim KouhsariLaboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Saeed KhoshnoodClinical Microbiology Research Center, Ilam University of Medical Sciences, Ilam, Iran.
Khalil AzizianDepartment of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. k.azizian86@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMethicillin-resistant Staphylococcus aureus (MRSA) infections are considered an important public health problem, and treatment options are limited. Accordingly, in this meta-analysis, we analyzed published studies to survey in vitro activity of recently approved antibiotics against MRSA isolates.

methodsWe searched electronic databases; PubMed, Scopus, and Web of Science to identify relevant studies (until November 30, 2020) that have focused on the in vitro activity of telavancin, dalbavancin, oritavancin, and tedizolid against MRSA isolates. Statistical analyses were conducted using STATA software (version 14.0).

resultsThirty-eight studies were included in this meta-analysis. Overall in vitro activity of tedizolid on 12,204 MRSA isolates was 0.250 and 0.5 µg/mL for MIC

conclusionTelavancin, dalbavancin, oritavancin, and tedizolid had potent in vitro activity against MRSA isolates. The low MICs and high susceptibility rates of these antibiotics recommend a hopeful direction to introduce useful antibiotics in treating MRSA infections in the future.

Indexed as

Methicillin-Resistant Staphylococcus aureusStaphylococcal InfectionsAnti-Bacterial AgentsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsAntibacterial activityDalbavancinLipoglycopeptideMRSAOritavancinTedizolidTelavancin

Identifiers

PMID35978400
PMCPMC9382732

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.