Observational studyBMC musculoskeletal disorders2022
Quadriceps strength is negatively associated with knee joint structural abnormalities-data from osteoarthritis initiative.
Observational study in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.
- Optimizing resistance training for pain management in knee and hip osteoarthritis: a pairwise and dose-response meta-analysis.Frontiers in public health · 2025Pooled it
- Effects of Blood-Flow Restricted Resistance Exercise Versus Neuromuscular Exercise on Mechanical Muscle Function in Adults With Chronic Knee Osteoarthritis-A Secondary Analysis From a Randomized Controlled Trial.Scandinavian journal of medicine & science in sports · 2025Trial
- The prevalence and influencing factors of dynapenia among middle-aged and elderly individuals with knee osteoarthritis: a cross-sectional analysis.BMC musculoskeletal disorders · 2026Article
- Assessment of Quadriceps Muscle Characteristics in Female Division I Athletes: A Validation Study of Wireless Probes Against Standard Ultrasound Units.Journal of sport rehabilitation · 2026Article
- Baseline loss of knee extension is associated with regional MRI progression in knee osteoarthritis: a retrospective longitudinal cohort study-data from the osteoarthritis initiative.Rheumatology international · 2025Article
- Reduced Muscle Strength Can Alter the Impact of Gait Modifications on Knee Cartilage Mechanics.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- The effect of blood flow restriction combined with neuromuscular electrical stimulation on knee joint function: A systematic review and meta-analysis.Journal of orthopaedics · 2025Review
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Weight Loss, but Not at Any Cost: Risks and Challenges in Patients with Osteoarthritis.Mediterranean journal of rheumatology · 2025Review
- Trends in knee osteoarthritis prevalence over a 10-year period in Japan: The ROAD study 2005-2015.Osteoarthritis and cartilage open · 2025Article
- Obesity, Osteoarthritis, and Myokines: Balancing Weight Management Strategies, Myokine Regulation, and Muscle Health.Nutrients · 2024Review
- Comparison of the asymmetries in muscle mass, biomechanical property and muscle activation asymmetry of quadriceps femoris between patients with unilateral and bilateral knee osteoarthritis.Frontiers in physiology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe aim of this study was to explore the longitudinal associations between baseline quadriceps strength and knee joint structural abnormalities in knee osteoarthritis (KOA).
methodsThis study is a longitudinally observational study based on Osteoarthritis Initiative (OAI) cohort, including men and women aged 45-79. Quadriceps strength was measured by isometric knee extension testing at baseline. Knee joint structural abnormalities, including cartilage damage, bone marrow lesions (BMLs), effusion-synovitis and Hoffa-synovitis, were evaluated by Magnetic Resonance Imaging Osteoarthritis Knee Score (MOAKS) at baseline and 1-year follow-up. Generalized estimating equations were employed to examine the associations between quadriceps strength and knee structural abnormalities. All analyses were stratified by sex.
resultsOne thousand three hundred thirty-eight participants (523 men and 815 women) with a mean age of 61.8 years and a mean BMI of 29.4 kg/m
conclusionsHigher quadriceps strength was associated with changes in cartilage damage and BMLs within the lateral PFJ and effusion-synovitis among females, suggesting the potential protective role of quadriceps strength on joint structures in women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.