Evidence map›Paper›PMID 35978310›Full record

ArticleBMC neurology2022

Expression of TRAF6 in peripheral blood B cells of patients with myasthenia gravis.

Ting Li, Yue Li, Jia-Wen Li, Ying-Hui Qin, Hui Zhai, Bin Feng, He Li, Ning-Nannan Zhang, Chun-Sheng Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Ting Li *Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China. liting200401@126.com.
Yue Li *Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.
Jia-Wen Li *Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.
Ying-Hui QinDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.
Hui ZhaiDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.
Bin FengDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.
He LiDepartment of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Ning-Nannan ZhangDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, School of Medical Imaging, Tianjin Medical University General Hospital, Tianjin Medical University, No. 154 Anshan Road, Heping District, Tianjin, 300052, China.
Chun-Sheng YangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, No. 154 Anshan Road, Heping District, Tianjin, 300052, China. cyang01@tmu.edu.cn.
Tianjin Medical University General Hospital · CNTianjin Huanhu Hospital · CN

Funding

National Natural Science Foundation of China 82071907National Natural Science Foundation of China 82171338Youth Incubation Fund of Tianjin Medical University General Hospital ZYYFY2019008
6 · The paper itself

Abstract

backgroundTumor necrosis factor receptor-associated factor 6 (TRAF6) can regulate the activation of inflammatory signaling pathways by acting as an E3 ubiquitin ligase, which enhances B cell activation. This study aimed to evaluate the expression of TRAF6 in the peripheral blood B cells of myasthenia gravis (MG) patients and analyze the relationships between TRAF6 expression and clinical characteristics.

methodIn our study, the expression level of TRAF6 in peripheral blood B cells of 89 patients was measured by flow cytometry compared with that of healthy subjects. The effects of disease severity, MG classification and immunotherapy on TRAF6 expression level were also analyzed.

resultsIn our study, TRAF6 expression was elevated in CD19

conclusionTRAF6 is potentially a useful biomarker of inflammation in patients with MG, and might be used to evaluate the effectiveness of treatment.

Indexed as

Myasthenia GravisTNF Receptor-Associated Factor 6B-LymphocytesHumansIntracellular Signaling Peptides and ProteinsLymphocyte CountIntracellular Signaling Peptides and ProteinsTifab protein, humanTNF Receptor-Associated Factor 6ADL-scoreB cellMemory B cellMyasthenia gravisTumor necrosis factor receptor (TNFR)-associated factor 6 (TRAF6)

Identifiers

PMID35978310
PMCPMC9382794
OpenAlexW4292266800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.