Evidence map›Paper›PMID 35978296›Full record

ArticleBMC cardiovascular disorders2022

The constricting effect of reduced coronary artery compliance on the left ventricle is an important cause of reduced diastolic function in patients with coronary heart disease.

Liang Lv, Xianghe Ma, Yannan Xu, Qiong Zhang, Shanshan Kan, Xiaoming Chen, Huajin Liu, Hongwei Wang, Changhua Wang, Jiangwei Ma

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cardiovascular disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Liang LvThe Third Affiliated Hospital, Southern Medical University or The Third School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Xianghe MaShanghai Maritime University, Shanghai, China.
Yannan XuAnhui University of Science and Technology, Huainan, Anhui, China.
Qiong ZhangDepartment of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Nanfeng Road 6600#, Shanghai, 201400, China.
Shanshan KanAnhui University of Science and Technology, Huainan, Anhui, China.
Xiaoming ChenAnhui University of Science and Technology, Huainan, Anhui, China.
Huajin LiuDepartment of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Nanfeng Road 6600#, Shanghai, 201400, China.
Hongwei WangDepartment of Cardiology, Fengxian Branch of Shanghai 6th People's Hospital, Nanfeng Road 6600#, Shanghai, 201400, China.
Changhua WangTengZhou City Central People Hospital, Affiliated to Jining Medical University, Jining, Shandong, China.
Jiangwei MaThe Third Affiliated Hospital, Southern Medical University or The Third School of Clinical Medicine, Southern Medical University, Guangzhou, Guangdong, China. majiangwei2004@126.com.
Anhui University of Science and Technology · CNJining Medical University · CNShanghai Maritime University · CNThird Affiliated Hospital of Southern Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies of left ventricular diastolic function (LVDF) have focused on the decrease in active and passive diastolic function due to ischemic factors but have not investigated if the decrease in compliance of the coronary arteries that bypass the surface of the heart and travel between the myocardium could cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis. METHODS AND

results581 patients diagnosed with coronary heart disease (CHD) were divided into A group (patients are the control group), B group (patients with less than 50% coronary artery stenosis), C group (patients with coronary artery stenosis between 50 and 75%), D group (patients with coronary artery stenosis greater than 75%) according to the degree of coronary stenosis. The diastolic function of the ventricle is reflected by applying the relaxation time constant T value, which refers to the time between peak dp/dt and end-diastolic pressure in the left ventricle. It was concluded that there was a statistical difference in Gensini scores between patients in groups B, C and D (P < 0.001). And multiple linear regression analysis showed that T was correlated with Gensini score and C-dp/dtmax (R = 0.711, P < 0.001). Grouping according to the site of stent implantation and the number of stents implanted, it was found out that the changes in T values before and after left anterior descending artery (LAD) stent implantation were greater than left circumflex artery (LCX) and right coronary artery (RCA) (P < 0.001). And multiple linear regression revealed a correlation between T values and stent length, ventricular stiffness, and C-dp/dtmax (P = 0.001).

conclusionsThe decrease in compliance of the coronary arteries bypassing the surface of the heart and travelling between the myocardium would cause a constricting effect on the ventricular wall like that caused by myocardial fibrosis.

Indexed as

Coronary StenosisCoronary VesselsDiastoleFibrosisHeart VentriclesHumansCoronary heart diseaseLeft ventricular diastolic functionPCIStent implantation

Identifiers

PMID35978296
PMCPMC9382726
OpenAlexW4292260441

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.