Evidence map›Paper›PMID 35978192›Full record

ArticleNature2022

MYB orchestrates T cell exhaustion and response to checkpoint inhibition.

Carlson Tsui, Lorenz Kretschmer, Svenja Rapelius, Sarah S Gabriel, David Chisanga, Konrad Knöpper, Daniel T Utzschneider, Simone Nüssing, Yang Liao, Teisha Mason and 12 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers.

0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed
18.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

183 citing papers in PubMed, 230 citations in OpenAlex.

  1. Distinct CD8Cancer cell · 2025
    Trial
  2. Article
  3. Article
  4. Article
  5. Dendritic cell PD-L2 restrains intratumoral CD8bioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Exhausted CD8Nature immunology · 2026
    Article
  11. Article
  12. Article
  13. Single-Cell Pan-Cancer Atlas Reveals GPR171 as a Candidate Marker of CD8International journal of molecular sciences · 2026
    Article
  14. Article
  15. Article
  16. Lymph node fine-tuning FcγR signaling boosts anti-PD-1 therapy.Journal for immunotherapy of cancer · 2026
    Article
  17. Article
  18. Article
  19. Review
  20. Article

123 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

22 authors at 5 institutions in 2 countries.

Carlson Tsui *Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-0642-814X
Lorenz Kretschmer *Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0003-0987-8429
Svenja Rapelius *Institute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Sarah S GabrielDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
David ChisangaOlivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-0421-3957
Konrad KnöpperWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0003-2076-2160
Daniel T UtzschneiderDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-2205-9057
Simone NüssingPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Yang LiaoOlivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-9746-2839
Teisha MasonDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Santiago Valle TorresDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia.
Stephen A WilcoxThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Krystian KanevDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany.
Sebastian JaroschInstitute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich (TUM), Munich, Germany.ORCID http://orcid.org/0000-0002-2908-8590
Justin LeubeInstitute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich (TUM), Munich, Germany.
Stephen L NuttThe Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0002-0020-6637
Dietmar ZehnDivision of Animal Physiology and Immunology, School of Life Sciences Weihenstephan, Technical University of Munich (TUM), Freising, Germany.ORCID http://orcid.org/0000-0003-1393-8527
Ian A ParishPeter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID http://orcid.org/0000-0003-3528-478X
Wolfgang KastenmüllerWürzburg Institute of Systems Immunology, Max Planck Research Group, Julius-Maximilians-Universität Würzburg, Würzburg, Germany.ORCID http://orcid.org/0000-0002-3835-1485
Wei ShiOlivia Newton-John Cancer Research Institute, Melbourne, Victoria, Australia.
Veit R BuchholzInstitute for Medical Microbiology, Immunology and Hygiene, School of Medicine, Technical University of Munich (TUM), Munich, Germany. veit.buchholz@tum.de.ORCID http://orcid.org/0000-0003-0441-3913
Axel KalliesDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, University of Melbourne, Melbourne, Victoria, Australia. axel.kallies@unimelb.edu.au.ORCID http://orcid.org/0000-0002-6312-6968
The University of Melbourne · AUTechnical University of Munich · DEUniversity of Würzburg · DEWalter and Eliza Hall Institute of Medical Research · AUInstitute of Medical Microbiology and Hygiene · DE

Funding

European Research Council 949719
6 · The paper itself

Abstract

CD8

Indexed as

CD8-Positive T-LymphocytesProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-mybCell ProliferationCell Self RenewalHepatocyte Nuclear Factor 1-alphaImmunotherapyL-SelectinPrecursor Cells, T-LymphoidVirusesHepatocyte Nuclear Factor 1-alphaL-SelectinProgrammed Cell Death 1 ReceptorProto-Oncogene Proteins c-myb

Identifiers

PMID35978192
PMCPMC9452299
OpenAlexW4292121925

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.