ArticleNature2022
Endocytosis in the axon initial segment maintains neuronal polarity.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
6.5field-weighted citation impact, top 2% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 63 citations in OpenAlex.
- From Pits to Plaques: Electron Microscopy Reveals Clathrin Structural Plasticity in Trafficking, Sorting and Adhesion.Traffic (Copenhagen, Denmark) · 2026Review
- Loss of endogenous tau suppresses APOE4-induced patterned behavioral decline and axon dysmorphia in a model of Alzheimer's disease.Disease models & mechanisms · 2026Article
- Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity.Neuron · 2026Article
- Stochastic growth and ligand-receptor interaction-mediated stabilization generate stereotyped dendritic arbors.Nature neuroscience · 2026Article
- Abl kinase activation promotes axon initial segment disassembly and protein sorting defects in Alzheimer's disease.BMC biology · 2026Article
- Axon Initial Segment: Structure, Biological Functions, Diseases, and Therapeutic Targets.MedComm · 2026Review
- Impaired motor activity in a CRISPR SCA5 L253P knock-in mouse is associated with selective β-III-spectrin subcellular redistribution in the cerebellum.bioRxiv : the preprint server for biology · 2026Article
- Mislocalization of KCNQ2 Channels as a Pathogenic Mechanism in KCNQ2 Developmental and Epileptic Encephalopathy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- An epidermal membrane-associated periodic skeleton restricts endocytosis to stabilize neuron-epidermal attachment and preserve axons.Science advances · 2026Article
- Formation, Organization, and Maintenance of Synaptic Vesicle Pools: From Molecules to Structure and Dynamics.Advances in neurobiology · 2026Review
- Mechanistic insights into cargo sorting and export from the Golgi apparatus.Nature reviews. Molecular cell biology · 2025Review
- A dendritic guidance receptor functions in both ligand dependent and independent modes.PLoS genetics · 2025Article
- Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly.bioRxiv : the preprint server for biology · 2025Article
- Expansion of lysosomal capacity in early adult neurons driven by TFEB/HLH-30 protects dendrite maintenance during aging in Caenorhabditis elegans.PLoS biology · 2025Article
- Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity.bioRxiv : the preprint server for biology · 2025Article
- Sculpting excitable membranes: voltage-gated ion channel delivery and distribution.Nature reviews. Neuroscience · 2025Review
- Axon initial segment structure and function in health and disease.Physiological reviews · 2025Review
- A dendritic guidance receptor functions in both ligand dependent and independent modes.bioRxiv : the preprint server for biology · 2025Article
- The kinetochore protein KNL-1 regulates the actin cytoskeleton to control dendrite branching.The Journal of cell biology · 2025Article
- Unveiling the cell biology of hippocampal neurons with dendritic axon origin.The Journal of cell biology · 2025Article
Corrections and comments
- Erratum issued
Authors and funding
13 authors at 4 institutions in 2 countries.
Kelsie EichelHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-4507-5949
Takeshi UenakaDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Vivek BelapurkarUniversity of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, Bordeaux, France.ORCID http://orcid.org/0000-0002-1132-0873
Rui LuDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.
Shouqiang ChengDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Joseph S PakDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.
Caitlin A TaylorHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA, USA.
Thomas C SüdhofDepartment of Molecular and Cellular Physiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-3361-9275
Robert MalenkaNancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5428-5211
Marius WernigDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-5309-515X
Engin ÖzkanDepartment of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-0263-6729
David PerraisUniversity of Bordeaux, CNRS, Interdisciplinary Institute for Neuroscience, Bordeaux, France.ORCID http://orcid.org/0000-0002-5878-5408
Kang ShenHoward Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA, USA. kangshen@stanford.edu.ORCID http://orcid.org/0000-0003-4059-8249
Howard Hughes Medical Institute · USStanford University · USUniversity of Chicago · USCentre National de la Recherche Scientifique · FR
Funding
Molecular Recognition Principles, Engineering and Function of Neural Wiring ReceptorsR01NS097161 · NINDS · UNIVERSITY OF CHICAGO · PI OZKAN, ENGIN · 2016 to 2020
$1.8MHoward Hughes Medical InstituteNINDS NIH HHS R01 NS097161
Abstract
Neurons are highly polarized cells that face the fundamental challenge of compartmentalizing a vast and diverse repertoire of proteins in order to function properly
Indexed as
Axon Initial SegmentCell PolarityEndocytosisAnimalsCaenorhabditis elegansCell MembraneDendritesDiffusionEndosomesHumansMiceProtein TransportProteolysisRatsReceptors, Cell SurfaceReceptors, Cell Surface
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What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.