ArticleNature2022
Post-translational control of beige fat biogenesis by PRDM16 stabilization.
Open access · hybridAbstract read
In one paragraph
Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 2 pooled it
11.6field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
74 citing papers in PubMed, 2 syntheses or guidelines pooled it, 105 citations in OpenAlex.
- Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review.Cells · 2025Pooled it
- Genetic determinants of skin ageing: a systematic review and meta-analysis of genome-wide association studies and candidate genes.Journal of physiological anthropology · 2025Pooled it
- PRDM16 as a Multifaceted Pharmacological Target in Kidney Diseases: From Epigenetic Mechanisms to Therapeutic Strategies.Pharmaceuticals (Basel, Switzerland) · 2026Review
- E4BP4 safeguards brown fat mitochondria from obesity-induced fragmentation via ceramide repression.EMBO reports · 2026Article
- E3 ligase FBXO2-mediated protein stability of insulin receptor regulates adipogenesis and metabolic health in obesity.Cell death & disease · 2026Article
- E3 ligase SMURF2 promotes adipogenesis and improves obesity complications by suppressing TGF-β signaling.Journal of lipid research · 2026Article
- Nitrate-Sialin2 axis couples ER-mitochondrial calcium signaling with fatty acid metabolism to drive white adipose browning.Nature communications · 2026Article
- Article
- PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- PRDM16 protects retinal ganglion cells from ischemia-reperfusion Injury by regulating the RPL5/p53 axis.Cellular and molecular life sciences : CMLS · 2026Article
- The Roles of the PRDM Family in the Neuro-Motor System.Biomolecules · 2026Review
- Ontogeny Dictates Oncogenic Potential, Lineage Hierarchy, and Therapy Response in Pediatric Leukemia.Cancer discovery · 2026Article
- White-to-brown adipose switching promotes bladder cancer progression.Neoplasia (New York, N.Y.) · 2026Article
- Circular RNAs in metabolic health: bridging the gap between molecular biology and therapy.Cell death & disease · 2026Review
- RORγtScience immunology · 2026Article
- SEMA3E promotes beige adipocyte differentiation and thermogenesis via β-catenin signaling in mice.Apoptosis : an international journal on programmed cell death · 2026Article
- Optimizing adipogenic cocktail composition to enhance beige adipogenesis and evaluate thermogenic potential in primary mouse subcutaneous fat cell cultures.International journal of obesity (2005) · 2026Article
- KLHDC3 deficiency in mice reveals essential roles in development, survival, and adiposity via the DesCEND ubiquitin pathway.BMC genomics · 2026Article
- Distinct precursor landscape of subcutaneous and visceral fat in development and aging.Cell reports · 2026Review
- NIR-activated adipose-targeted nanocarrier drives local browning and metabolic restoration.Regenerative biomaterials · 2026Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 3 countries.
Qiang WangDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Huixia LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, China.
Kazuki TajimaDepartment of Endocrinology and Metabolism, National Hospital Organization, Yokohama Medical Center, Yokohama, Japan.
Anthony R P VerkerkeDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-6198-4723
Zachary H TaxinDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Zhishuai HouDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Joanne B ColePrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID http://orcid.org/0000-0001-9520-2788
Fei LiDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Jake WongDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.
Ichitaro AbeDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2769-5338
Rachana N PradhanOncology Bioinformatics, Genentech, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-7352-8111
Tadashi YamamuroDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0610-5204
Takeshi YoneshiroDivision of Metabolic Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo, Japan.
Joel N HirschhornPrograms in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Shingo KajimuraDivision of Endocrinology, Diabetes and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. skajimur@bidmc.harvard.edu.ORCID http://orcid.org/0000-0003-0672-5910
Beth Israel Deaconess Medical Center · USBroad Institute · USNational Hospital Organization · JPThe University of Tokyo · JPXi'an Jiaotong University · CN
Funding
Cell Interactions in the Inflamed Intestinal MucosaR01DK075787 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI JOEL N HIRSCHHORN · 2007 to 2026
$13.1MINTEGRATED ENDOCRINE &METABOLIC RESEARCH TRAININGT32DK007516 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BARBARA B. KAHN · 1986 to 2026
$6.8MMolecular mechanisms of UCP1-independent pathways in metabolic healthR01DK097441 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Shingo Kajimura · 2012 to 2026
$5.9MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Deborah J Wexler · 2023 to 2026
$5.4MPost-translational control of adipose tissue remodeling and metabolic healthR01DK127575 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2020 to 2025
$2.6MCalRepository: A database of indirect calorimetry experiments for the study of energy homeostasisR01DK133948 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2022 to 2025
$2.0MMolecular control of beige fat heterogeneityR01DK125281 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2020 to 2023
$1.9MMitochondrial BCAA transporter in physiology and diseaseR01DK125283 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI KAJIMURA, SHINGO · 2021 to 2025
$1.8MInstrumentation for Noninvasive Measurement of Glucose and Energy Balance in Mice with Continuous Glucose Telemetry and Indirect CalorimetryS10OD028635 · OD · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BANKS, ALEXANDER · 2020 to 2020
$737kGenetically harmonized dietary intake and causal relationships with diabetes-related outcomesK99DK127196 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI COLE, JOANNE BURNETTE · 2021 to 2022
$178kHoward Hughes Medical InstituteMedical Research Council MC_PC_17228Medical Research Council MC_QA137853NIDDK NIH HHS K99 DK127196NIDDK NIH HHS P30 DK135043NIDDK NIH HHS R01 DK075787NIDDK NIH HHS R01 DK097441NIDDK NIH HHS R01 DK125281NIDDK NIH HHS R01 DK125283NIDDK NIH HHS R01 DK127575NIDDK NIH HHS R01 DK133948NIDDK NIH HHS T32 DK007516NIH HHS S10 OD028635
Abstract
Compelling evidence shows that brown and beige adipose tissue are protective against metabolic diseases
Indexed as
Adipose Tissue, BeigeDNA-Binding ProteinsTranscription FactorsAdipocytes, BeigeAdipose Tissue, BrownAnimalsCullin ProteinsDyslipidemiasGlucose IntoleranceInsulin ResistanceMiceObesityProtein StabilityThermogenesisUbiquitinationUbiquitin-Protein Ligase ComplexesAppbp2 protein, mouseCul2 protein, mouseCullin ProteinsDNA-Binding ProteinsPrdm16 protein, mouseTranscription FactorsUbiquitin-Protein Ligase Complexes
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What OpenQuestion holds
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.