Evidence map›Paper›PMID 35978042›Full record

ArticleNeuroradiology2023

Brain functional connectivity differences between responders and non-responders to sleeve gastrectomy.

Carlo A Mallio, Giuseppe Spagnolo, Claudia Piervincenzi, Nikolaos Petsas, Danilo Boccetti, Federica Spani, Ida Francesca Gallo, Antonella Sisto, Livia Quintiliani, Gianfranco Di Gennaro and 2 more

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Article in Neuroradiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A review of brain structural and functional changes using MRI technology in patients who received bariatric surgery.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carlo A MallioUnit of Diagnostic Imaging, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy. c.mallio@policlinicocampus.it.ORCID http://orcid.org/0000-0002-0149-0801
Giuseppe SpagnoloUnit of Bariatric Surgery, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, Italy.
Claudia PiervincenziDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Nikolaos PetsasDepartment of Radiology, IRCCS NEUROMED, Pozzilli, Italy.
Danilo BoccettiDepartment of Biotechnological and Applied Clinical Science, University of L'Aquila AQ, L'Aquila, Italy.
Federica SpaniUnit of Diagnostic Imaging, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy.
Ida Francesca GalloUnit of Bariatric Surgery, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, Italy.
Antonella SistoClinical Psychological Service, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, Italy.
Livia QuintilianiClinical Psychological Service, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, Italy.
Gianfranco Di GennaroDepartment of Health Sciences, Chair of Medical Statistics, University of Catanzaro Magna Græcia, Catanzaro, Italy.
Vincenzo BruniUnit of Bariatric Surgery, Fondazione Policlinico Universitario Campus Bio-Medico di Roma, Rome, Italy.
Carlo C QuattrocchiUnit of Diagnostic Imaging, Fondazione Policlinico Universitario Campus Bio-Medico Di Roma, Via Alvaro del Portillo, 21, 00128, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare resting-state functional connectivity (RSFC) of obese patients responders or non-responders to sleeve gastrectomy (SG) with a group of obese patients with no past medical history of metabolic or bariatric surgery.

methodsMR images were acquired at 1.5 Tesla. Resting-state fMRI data were analyzed with statistical significance threshold set at p < 0.05, family-wise error (FWE) corrected.

resultsSixty-two subjects were enrolled: 20 controls (age range 25-64; 14 females), 24 responders (excess weight loss > 50%; age range 23-68; 17 females), and 18 non-responders to sleeve gastrectomy (SG) (excess weight loss < 50%; age range 23-67; 13 females). About within-network RSFC, responders showed significantly lower RSFC with respect to both controls and non-responders in the default mode and frontoparietal networks, positively correlating with psychological scores. Non-responders showed significantly higher (p < 0.05, family-wise error (few) corrected) RSFC in regions of the lateral visual network as compared to controls. Regarding between-network RSFC, responders showed significantly higher anti-correlation between executive control and salience networks (p < 0.05, FWE corrected) with respect to both controls and non-responders. Significant positive correlation (Spearman rho = 0.48, p = 0.0012) was found between % of excess weight loss and executive control-salience network RSFC.

conclusionThere are differences in brain functional connectivity in either responders or non-responders patients to SG. The present results offer new insights into the neural correlates of outcome in patients who undergo SG and expand knowledge about neural mechanisms which may be related to surgical response.

Indexed as

BrainBrain MappingAdultAgedFemaleGastrectomyHumansMagnetic Resonance ImagingMiddle AgedObesityWeight LossYoung AdultBariatric surgeryBrain connectivityfMRIObesitySleeve gastrectomy

Identifiers

PMID35978042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.