Evidence map›Paper›PMID 35977628›Full record

ArticleNeuropharmacology2022

Dose-dependent suppression of hippocampal contextual memory formation, place cells, and spatial engrams by the NMDAR antagonist (R)-CPP.

Mengwen Zhu, Mark G Perkins, Richard Lennertz, Alifayaz Abdulzahir, Robert A Pearce

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Mengwen ZhuDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: mzhu93@wisc.edu.
Mark G PerkinsDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: mgperkins@wisc.edu.
Richard LennertzDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: rlennertz@wisc.edu.
Alifayaz AbdulzahirDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: abdulzahir@wisc.edu.
Robert A PearceDepartment of Anesthesiology, University of Wisconsin-Madison, Madison, WI, 53705, USA. Electronic address: rapearce@wisc.edu.
University of Wisconsin–Madison · US

Funding

Waisman Center Intellectual and Developmental Disabilities Research CenterP50HD105353 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI Brittany Gail Travers · 2021 to 2026
$8.5M
Anesthetic Suppression of Memory through disinhibitory circuits in HippocampusR01GM118801 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI PEARCE, ROBERT A · 2016 to 2019
$1.9M
An Upright Multiphoton Microscopy System to Support the Biomedical SciencesS10OD025040 · OD · UNIVERSITY OF WISCONSIN-MADISON · PI AUDHYA, ANJON · 2018 to 2018
$597k
NICHD NIH HHS P50 HD105353NIGMS NIH HHS R01 GM118801NIH HHS S10 OD025040
6 · The paper itself

Abstract

We recently reported that the competitive NMDAR antagonist (R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP) does not suppress NMDAR-mediated field EPSPs (fEPSP

Indexed as

Place CellsAnimalsHippocampusMemoryMiceN-MethylaspartateReceptors, N-Methyl-D-AspartateN-MethylaspartateReceptors, N-Methyl-D-AspartateContext preexposure facilitation effect (CPFE)Contextual fear memoryIn-vivo calcium imagingNMDA receptors (NMDARs)Place cell(R)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid ((R)-CPP)(R,S)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP)Spatial engram

Identifiers

PMID35977628
PMCPMC9673467
OpenAlexW4291335287

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.