ArticleCell reports2022
Genetic impairment of succinate metabolism disrupts bioenergetic sensing in adrenal neuroendocrine cancer.
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Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
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- An integrated bioinformatic investigation of succinic acid metabolism related genes in ccRCC followed by preliminary validation of SLC25A4 in tumorigenesis.Scientific reports · 2025Article
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- Succinate Dehydrogenase and Human Disease: Novel Insights into a Well-Known Enzyme.Biomedicines · 2024Review
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Corrections and comments
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Authors and funding
21 authors at 11 institutions in 4 countries.
Priyanka GuptaDepartment of Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA.
Keehn StrangeDepartment of Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA.
Rahul TelangeDepartment of Hematology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Ailan GuoCell Signaling Technology, Danvers, MA 01923, USA.
Heather HatchDepartment of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA.
Amin SobhDepartment of Medicine, Division of Hematology and Oncology, University of Florida, Gainesville, FL 32608, USA.
Jonathan EliePerha Pharmaceuticals, Hôtel de Recherche, Perharidy Peninsula, 29680 Roscoff, France.
Angela M CarterDepartment of Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA.
John TotenhagenDepartment of Radiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA.
Chunfeng TanUT Health Science Center at Houston, Department of Neurology, University of Texas McGovern Medical School, Houston, TX 77030, USA.
Yogesh A SonawaneEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Jiri NeuzilInstitute of Biotechnology, Czech Academy of Sciences, Prague-West 252 50, Czech Republic; School of Pharmacy Medical Science, Griffith University, Southport, QLD 4222, Australia.
Amarnath NatarajanEppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Ashley J OvensMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.
Jonathan S OakhillMetabolic Signalling Laboratory, St Vincent's Institute of Medical Research, Fitzroy, VIC, Australia; Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC, Australia.
Thorsten WiederholdCell Signaling Technology, Danvers, MA 01923, USA.
Karel PacakSection on Medical Neuroendocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Hans K GhayeeDepartment of Internal Medicine, Division of Endocrinology, University of Florida College of Medicine and Malcom Randall VA Medical Center, Gainesville, FL 32608, USA.
Laurent MeijerPerha Pharmaceuticals, Hôtel de Recherche, Perharidy Peninsula, 29680 Roscoff, France.
Sushanth ReddyDepartment of Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA.
James A BibbDepartment of Surgery, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA; O'Neal Comprehensive Cancer Center and the Department of Neurobiology, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL 35233, USA. Electronic address: jbibb@uab.edu.
University of Alabama at Birmingham · USAustralian Catholic University · AUCell Signaling Technology (United States) · USManRos Therapeutics (France) · FRUniversity of Florida · USUniversity of Nebraska Medical Center · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USGriffith University · AUMalcom Randall VA Medical Center · USSt. Jude Children's Research Hospital · USThe University of Texas Health Science Center at Houston · US
Funding
XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9MUniversity of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5MTissue CoreP50CA127297 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLLINGSWORTH, MICHAEL A. · 2008 to 2018
$17.1MPancreatic Cancer Detection ConsortiumU01CA210240 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Michael A. Hollingsworth · 2017 to 2026
$12.9MPERIPHERAL INFLAMMATION AND STRESS DRIVE VENTRAL STRIATAL MALADAPTATIONSR01MH126948 · NIMH · UNIVERSITY OF ARIZONA · PI BIBB, JAMES A · 2021 to 2025
$2.5MExcitatory and Metabotopic Regulation of PKA in Stress and ResilienceR01MH116896 · NIMH · UNIVERSITY OF ARIZONA · PI BIBB, JAMES A · 2019 to 2022
$1.5MMajor upgrade for UAB Bruker BioSpec preclinical 9.4T MRIS10OD028498 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SORACE, ANNA C · 2020 to 2020
$601kExcitatory and Metabotopic Regulation of PKA in Stress and ResilienceR56MH116896 · NIMH · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BIBB, JAMES A · 2018 to 2018
$371kNCI NIH HHS P30 CA013148NCI NIH HHS P50 CA127297NCI NIH HHS U01 CA210240NIDDK NIH HHS P30 DK079626NIH HHS S10 OD028498NIMH NIH HHS R01 MH116896NIMH NIH HHS R01 MH126948NIMH NIH HHS R56 MH116896
Abstract
Metabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of function of the mitochondrial tricarboxylic acid (TCA) cycle enzyme subunit succinate dehydrogenase B (SDHB) results in various forms of cancer typified by pheochromocytoma (PC). Here we delineate a signaling cascade where the loss of SDHB induces the Warburg effect, triggers dysregulation of [Ca
Indexed as
Adenylate KinaseCarcinoma, NeuroendocrineAnimalsCyclin-Dependent Kinase 5Energy MetabolismGlycogen Synthase Kinase 3MicePhosphorylationSuccinatesAdenylate KinaseCyclin-Dependent Kinase 5Glycogen Synthase Kinase 3SuccinatesAMPKcancer bioenergeticsCdk5CP: CancerCP: Metabolismneuroendocrine tumorp53pheochromocytomaPRKAG2SDHBsenescenceWarburg effect
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.