Evidence map›Paper›PMID 35977028›Full record

ReviewScience advances2022

The evolving role of tissue-resident memory T cells in infections and cancer.

Sasitorn Yenyuwadee, Jose Luis Sanchez-Trincado Lopez, Rushil Shah, Pamela C Rosato, Vassiliki A Boussiotis

Abstract readReview
In one paragraph

Review in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 95 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
95citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

95 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Mucosal immunity and vaccine development.Signal transduction and targeted therapy · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Article
  7. Review
  8. PD-1 regulates CD4Nature communications · 2026
    Article
  9. Article
  10. A pathogenic CD8⁺ TNature communications · 2026
    Article
  11. HIF-1αImmunity · 2026
    Article
  12. Article
  13. When Checkpoint Inhibitors Break Barriers: Mechanisms and Challenges of irAEs of the Skin, Gastrointestinal Tract, and Lung.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Review
  14. Article
  15. Article
  16. Review
  17. Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme A to Abrogate the Differentiation of CD103Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  18. Article
  19. Tumor-embedded Immunity and TRM Cell Functions in Cancer.Mini reviews in medicinal chemistry · 2026
    Review
  20. Review

35 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sasitorn YenyuwadeeDivision of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-5685-8271
Jose Luis Sanchez-Trincado LopezDivision of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Rushil ShahDivision of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-7060-4497
Pamela C RosatoThe Geisel School of Medicine at Dartmouth, Lebanon, NH 03755, USA.
Vassiliki A BoussiotisDivision of Hematology-Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.ORCID 0000-0002-3963-1518

Funding

Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MIERKE, DALE F · 2016 to 2025
$25.9M
Advancing Treatment Outcomes in Malignant Glioma by Integrating Immunotherapy and Standard of Care using Genetically Engineered Mice that Recapitulate Molecular Feature of Human GliomaR01CA229784 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUSSIOTIS, VASSILIKI A, CHAREST, ALAIN · 2018 to 2022
$3.3M
The effects of PD-1 on tumor-mediated “emergency” myelopoiesis and fate commitment of myeloid cells: Implications for anti-tumor immunityR01CA238263 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUSSIOTIS, VASSILIKI A · 2020 to 2024
$3.1M
Improving anti-tumor T cell immunity by targeting LDH-A functions beyond the Warburg effectR01CA212605 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BOUSSIOTIS, VASSILIKI A · 2017 to 2021
$2.8M
Function and regulation of brain resident memory T cellsK22AI148508 · NIAID · DARTMOUTH COLLEGE · PI ROSATO, PAMELA · 2021 to 2022
$269k
NCI NIH HHS R01 CA212605NCI NIH HHS R01 CA229784NCI NIH HHS R01 CA238263NIAID NIH HHS K22 AI148508NIGMS NIH HHS P20 GM113132
6 · The paper itself

Abstract

Resident memory T cells (T

Indexed as

Immunologic MemoryNeoplasmsCD8-Positive T-LymphocytesHumansImmunotherapyMemory T Cells

Identifiers

PMID35977028
PMCPMC9385156

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.