Evidence map›Paper›PMID 35976880›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Targeting of microvillus protein Eps8 by the NleH effector kinases from enteropathogenic

Georgina L Pollock, Andrey M Grishin, Cristina Giogha, Jiyao Gan, Clare V Oates, Paul J McMillan, Isabella Gaeta, Matthew J Tyska, Jaclyn S Pearson, Nichollas E Scott and 2 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 3 countries.

Georgina L PollockCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0002-4397-3043
Andrey M GrishinDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Cristina GioghaCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0002-9075-9840
Jiyao GanCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0002-6296-3254
Clare V OatesDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0002-3858-019X
Paul J McMillanBiological Optical Microscopy Platform and Department of Biochemistry & Pharmacology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC 3010, Australia.
Isabella GaetaDepartment of Cell and Developmental Biology, University Medical Center, Vanderbilt University School of Medicine, Nashville, TN.
Matthew J TyskaDepartment of Cell and Developmental Biology, University Medical Center, Vanderbilt University School of Medicine, Nashville, TN.ORCID 0000-0003-2238-6189
Jaclyn S PearsonCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.
Nichollas E ScottDepartment of Microbiology and Immunology, University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC 3000, Australia.ORCID 0000-0003-2556-8316
Miroslaw CyglerDepartment of Biochemistry, Microbiology and Immunology, University of Saskatchewan, Saskatoon, SK S7N 5E5, Canada.
Elizabeth L HartlandCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, Australia.ORCID 0000-0003-4254-2863
The University of Melbourne · AUHudson Institute of Medical Research · AUUniversity of Saskatchewan · CAVanderbilt University Medical Center · US

Funding

TRAINING PROGRAM IN CELLULAR, BIOCHEMICAL, &MOLECULAR ST32GM008554 · NIGMS · VANDERBILT UNIVERSITY · PI PATTON, JAMES G. · 1995 to 2020
$7.4M
Molecular basis of brush border assemblyR01DK095811 · NIDDK · VANDERBILT UNIVERSITY · PI MATTHEW J TYSKA · 2013 to 2026
$4.9M
Role of I-BAR proteins in enterocyte differentiationR01DK111949 · NIDDK · VANDERBILT UNIVERSITY · PI MATTHEW J TYSKA · 2017 to 2026
$4.2M
Myosin-2 function in the enterocyte terminal webR01DK125546 · NIDDK · VANDERBILT UNIVERSITY · PI TYSKA, MATTHEW J · 2021 to 2024
$1.4M
Department of Education and Training | Australian Research Council (ARC) FT200100270NIDDK NIH HHS R01 DK095811NIDDK NIH HHS R01 DK111949NIDDK NIH HHS R01 DK125546NIGMS NIH HHS T32 GM008554
6 · The paper itself

Abstract

Attaching and effacing (AE) lesion formation on enterocytes by enteropathogenic

Indexed as

Adaptor Proteins, Signal TransducingEnteropathogenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsPhosphotransferasesCell NucleusHumansMicrovilliPhosphorylationAdaptor Proteins, Signal TransducingEPS8 protein, humanEscherichia coli ProteinsNleH protein, E coliPhosphotransferasesEPECEps8kinasemicrovillusT3SS

Identifiers

PMID35976880
PMCPMC9407544
OpenAlexW4292117420

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.