Evidence map›Paper›PMID 35976696›Full record

ArticleMolecular biology of the cell2022

Evidence for low-level translation in human erythrocytes.

Sangeetha Devi Kumar, Debaleena Kar, Md Noor Akhtar, Belinda Willard, Debadrita Roy, Tanweer Hussain, Purusharth I Rajyaguru, Sandeep M Eswarappa

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In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Sangeetha Devi KumarDepartment of Biochemistry, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
Debaleena KarDepartment of Biochemistry, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
Md Noor AkhtarDepartment of Biochemistry, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
Belinda WillardProteomics and Metabolomics Core, The Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195.
Debadrita RoyDepartment of Biochemistry, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
Tanweer HussainDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
Purusharth I RajyaguruDepartment of Biochemistry, Indian Institute of Science, Bengaluru 560012, Karnataka, India.
Sandeep M EswarappaDepartment of Biochemistry, Indian Institute of Science, Bengaluru 560012, Karnataka, India.ORCID 0000-0002-7903-5198
Indian Institute of Science Bangalore · INCleveland Clinic Lerner College of Medicine · US

Funding

High-End Instrumentation (HEI) Grant Program (S10)S10OD023436 · OD · CLEVELAND CLINIC LERNER COM-CWRU · PI WILLARD, BELINDA BELLE · 2017 to 2017
$873k
NIH HHS S10 OD023436
6 · The paper itself

Abstract

It is generally believed that human mature erythrocytes do not possess functional ribosomes and therefore cannot synthesize proteins. However, the absence of translation is not consistent with the long lifespan of mature erythrocytes. They stay viable and functional for about 115 d in the circulatory system. Here, using a highly pure preparation of human mature erythrocytes, we demonstrate the presence of translation by polysome profiling, [

Indexed as

beta-GlobinsErythrocytes5' Untranslated Regionsalpha-GlobinsHumansMethioninePolyribosomesProtein Biosynthesis5' Untranslated Regionsalpha-Globinsbeta-GlobinsMethionine

Identifiers

PMID35976696
PMCPMC9635303
OpenAlexW4292103687

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.