Evidence map›Paper›PMID 35976596›Full record

ArticleInternational journal of computer assisted radiology and surgery2022

Automated quantification of cartilage quality for hip treatment decision support.

Adrian C Ruckli, Florian Schmaranzer, Malin K Meier, Till D Lerch, Simon D Steppacher, Moritz Tannast, Guodong Zeng, Jürgen Burger, Klaus A Siebenrock, Nicolas Gerber and 1 more

Open access · hybridAbstract read
In one paragraph

Article in International journal of computer assisted radiology and surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Adrian C Rucklisitem Center for Translational Medicine and Biomedical Entrepreneurship, Personalised Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-2028-4608
Florian SchmaranzerDepartment of Diagnostic-, Interventional- and Pediatric Radiology, Inselspital, University Hospital of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-8729-7243
Malin K MeierDepartment of Orthopaedic Surgery and Traumatology, Inselspital, University Hospital of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-8858-9213
Till D LerchDepartment of Diagnostic-, Interventional- and Pediatric Radiology, Inselspital, University Hospital of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-0475-0269
Simon D SteppacherDepartment of Orthopaedic Surgery and Traumatology, Inselspital, University Hospital of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0002-4907-8939
Moritz TannastDepartment of Orthopaedic Surgery and Traumatology, Fribourg Cantonal Hospital, University of Fribourg, Fribourg, Switzerland.ORCID https://orcid.org/0000-0002-2761-565X
Guodong Zengsitem Center for Translational Medicine and Biomedical Entrepreneurship, Personalised Medicine, University of Bern, Bern, Switzerland.
Jürgen Burgersitem Center for Translational Medicine and Biomedical Entrepreneurship, Personalised Medicine, University of Bern, Bern, Switzerland.
Klaus A SiebenrockDepartment of Orthopaedic Surgery and Traumatology, Inselspital, University Hospital of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-3627-4313
Nicolas Gerbersitem Center for Translational Medicine and Biomedical Entrepreneurship, Personalised Medicine, University of Bern, Bern, Switzerland. nicolas.gerber@sitem.unibe.ch.ORCID http://orcid.org/0000-0003-0308-699X
Kate Gerbersitem Center for Translational Medicine and Biomedical Entrepreneurship, Personalised Medicine, University of Bern, Bern, Switzerland.ORCID https://orcid.org/0000-0003-4086-4973
University Hospital of Bern · CHUniversity of Bern · CHUniversity of Fribourg · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePreservation surgery can halt the progress of joint degradation, preserving the life of the hip; however, outcome depends on the existing cartilage quality. Biochemical analysis of the hip cartilage utilizing MRI sequences such as delayed gadolinium-enhanced MRI of cartilage (dGEMRIC), in addition to morphological analysis, can be used to detect early signs of cartilage degradation. However, a complete, accurate 3D analysis of the cartilage regions and layers is currently not possible due to a lack of diagnostic tools.

methodsA system for the efficient automatic parametrization of the 3D hip cartilage was developed. 2D U-nets were trained on manually annotated dual-flip angle (DFA) dGEMRIC for femoral head localization and cartilage segmentation. A fully automated cartilage sectioning pipeline for analysis of central and peripheral regions, femoral-acetabular layers, and a variable number of section slices, was developed along with functionality for the automatic calculation of dGEMRIC index, thickness, surface area, and volume.

resultsThe trained networks locate the femoral head and segment the cartilage with a Dice similarity coefficient of 88 ± 3 and 83 ± 4% on DFA and magnetization-prepared 2 rapid gradient-echo (MP2RAGE) dGEMRIC, respectively. A completely automatic cartilage analysis was performed in 18s, and no significant difference for average dGEMRIC index, volume, surface area, and thickness calculated on manual and automatic segmentation was observed.

conclusionAn application for the 3D analysis of hip cartilage was developed for the automated detection of subtle morphological and biochemical signs of cartilage degradation in prognostic studies and clinical diagnosis. The segmentation network achieved a 4-time increase in processing speed without loss of segmentation accuracy on both normal and deformed anatomy, enabling accurate parametrization. Retraining of the networks with the promising MP2RAGE protocol would enable analysis without the need for B1 inhomogeneity correction in the future.

Indexed as

Cartilage, ArticularGadoliniumAcetabulumContrast MediaHip JointHumansMagnetic Resonance ImagingContrast MediaGadoliniumAutomaticBiochemicalDeep learningHip cartilageMorphologicalQuality metric

Identifiers

PMID35976596
PMCPMC9515031
OpenAlexW4292258992

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.