Evidence map›Paper›PMID 35976411›Full record

ArticleArchives of orthopaedic and trauma surgery2023

Does systemic lupus erythematosus impact the peri-operative complication rates following primary total knee arthroplasty? A national inpatient sample-based large-scale study.

Vibhu Krishnan Viswanathan, Vishaal Sakthivelnathan, Tejas Senthil, Anil Menedal, Prabhudev Prasad Purudappa, Varatharaj Mounasamy, Senthil Sambandam

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Article in Archives of orthopaedic and trauma surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Impact of systemic lupus erythematosus on adverse outcomes and readmission after total shoulder arthroplasty: a Nationwide Readmission Database analysis 2016-2020.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Vibhu Krishnan ViswanathanDepartment of MSK Oncology, University of Calgary, Calgary, AB, Canada. drvibu007@gmail.com.ORCID http://orcid.org/0000-0002-3804-1698
Vishaal SakthivelnathanSchool of Medicine, University of Texas Medical Branch, Texas, USA.
Tejas SenthilCarroll High School, Dallas, TX, USA.
Anil MenedalSalem VA Medical Center, Salem, VA, USA.
Prabhudev Prasad PurudappaBoston University, Staff orthopedic surgeon, Boston VAMC, Boston, MA, USA.
Varatharaj MounasamyDepartment of Orthopedics, Chief of Orthopedics, University of Texas Southwestern, Dallas VAMC, Dallas, TX, USA.
Senthil SambandamUniversity of Texas Southwestern, Staff Orthopedic Surgeon, Dallas VAMC, Dallas, TX, USA. sambandamortho@gmail.com.
Dallas VA Medical Center · USBoston University · USSalem VA Medical Center · USThe University of Texas Medical Branch at Galveston · USUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionConsequent to improved life expectancies, there has been a substantial increase in the proportion of patients with systemic lupus erythematosus (SLE) undergoing total knee arthroplasty (TKA) over the past 2 decades. In comparison to the other inflammatory disorders, the complication rates and post-operative outcome in patients with SLE are less clearly understood, owing to the paucity of evidence in the literature.

methodsPatients who underwent TKA between 2016 and 2019 were identified (ICD-10CMP code) using the National Inpatient Sample (NIS) database and then classified into one of the two groups, namely those with SLE (ICD-10-CM; code710.0) and those without SLE (NSLE). Demographic details, co-morbidities, details regarding hospital stay, costs incurred, and complications encountered of this patient cohort were analysed and compared between the two groups.

resultsOverall, among 5,58,361 patients undergoing TKA, 2,094 (0.38%) patients had SLE. The SLE group was significantly younger than NSLE population (62.2 ± 9.9 vs 66.7 ± 9.5 years; p < 0.001). The proportion of female and African-American patients was higher in the SLE group (p < 0.001). SLE patients had a significantly longer hospital stay (p < 0.001) and greater hospital-related expenditure (p < 0.001). Among the peri-operative complications, SLE patients had significantly greater risk of developing post-operative anemia (19.2% in SLE vs 15.3% in NSLE; p < 0.001), requiring blood transfusion (2.8% in SLE vs 1.5% in NSLE; p < 0.001), and acquiring peri-prosthetic joint infections (1.9% in SLE vs 1% in NSLE; p < 0.001).

conclusionThe presence of SLE significantly lengthens hospital stay, and augments the health-care-related costs in patients undergoing TKA. The rates of peri-prosthetic infections, post-operative anemia, and need for blood transfusions are significantly greater in SLE patients.

Indexed as

Arthroplasty, Replacement, KneeLupus Erythematosus, SystemicComorbidityFemaleHumansInpatientsLength of StayPostoperative ComplicationsComplicationsHealth care expenditureOutcomeSystemic lupus erythematosusTotal knee arthroplasty

Identifiers

PMID35976411
OpenAlexW4292259421

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.