Evidence map›Paper›PMID 35976295›Full record

ReviewArquivos de neuro-psiquiatria2022

Myasthenia gravis in clinical practice.

Eduardo de Paula Estephan, José Pedro Soares Baima, Antonio Alberto Zambon

Open access · goldAbstract readReview
In one paragraph

Review in Arquivos de neuro-psiquiatria, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 37 citations in OpenAlex.

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  13. COVID-19 Vaccination and Late-Onset Myasthenia Gravis: A New Case Report and Review of the Literature.International journal of environmental research and public health · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Eduardo de Paula EstephanUniversidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.ORCID 0000-0002-6807-1951
José Pedro Soares BaimaUniversidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.ORCID 0000-0003-2708-1181
Antonio Alberto ZambonUniversidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil.ORCID 0000-0002-5323-3778
Universidade de São Paulo · BRAdobe Systems (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyasthenia gravis is largely a treatable disease, but it can result in significant morbidity and even mortality, which can usually be avoided, or at least mitigated, with timely diagnosis and appropriate treatment of the disease. Objective: this review aims to summarize the main practical aspects of the diagnostic approach, treatment and care of myasthenic patients.

methodsThe authors performed a non-systematic critical review summarizing the main practical aspects of myasthenia gravis.

resultsMost patients with myasthenia have autoantibodies targeted at acetylcholine receptors or, less commonly, muscle-specific kinase - MuSK. Electrophysiology plays an important role in the diagnosis of neuromuscular junction dysfunction. The central clinical manifestation of myasthenia gravis is fatigable muscle weakness, which can affect eye, bulbar, respiratory, and limb muscles. With rare exceptions, patients have a good response to symptomatic treatment, but corticosteroids and/or immunosuppressants are usually also necessary to obtain good control of the manifestations of the disease.

conclusionKnowledge of the peculiar aspects of their clinical and electrophysiological presentations is important for the diagnosis. Likewise, specific treatment and response time to each drug are crucial for proper care.

Indexed as

Myasthenia GravisReceptor Protein-Tyrosine KinasesAutoantibodiesHumansMuscle WeaknessNeuromuscular JunctionReceptors, CholinergicAutoantibodiesReceptor Protein-Tyrosine KinasesReceptors, Cholinergic

Identifiers

PMID35976295
PMCPMC9491427
OpenAlexW4290975842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.