ArticleJournal of the American Chemical Society2022
A Catalytic Asymmetric Pictet-Spengler Platform as a Biomimetic Diversification Strategy toward Naturally Occurring Alkaloids.
Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- A Practical and Scalable-Oriented Enantioselective Synthesis of (Organic process research & development · 2026Article
- Transaminase and Norcoclaurine Synthase One-Pot Cascades Towards (1S)-Tetrahydroisoquinolines.Chembiochem : a European journal of chemical biology · 2026Article
- Integrated Life Cycle Assessment Guides Sustainability in Synthesis: Antiviral Letermovir as a Case Study.Journal of the American Chemical Society · 2025Article
- A glycan foldamer that uses carbohydrate-aromatic interactions to perform catalysis.Nature chemistry · 2025Article
- Organocatalytic Asymmetric Synthesis of Azabicyclo[2.1.1]hexanes.ACS catalysis · 2025Article
- Recent Advances in the Synthesis and Biological Activities of Quinolactacin and its Derivatives: A Comprehensive Review.Current organic synthesis · 2025Review
- Highly Acidic Electron-Rich Brønsted Acids Accelerate Asymmetric Pictet-Spengler Reactions by Virtue of Stabilizing Cation-π Interactions.Journal of the American Chemical Society · 2024Article
- Understanding the Enzyme (Journal of chemical information and modeling · 2024Article
- A genetic optimization strategy with generality in asymmetric organocatalysis as a primary target.Chemical science · 2024Article
- High Hydrostatic Pressure in the Modulation of Enzymatic and Organocatalysis and Life under Pressure: A Review.Molecules (Basel, Switzerland) · 2023Review
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2 authors at 1 institution in 1 country.
Funding
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Abstract
Tetrahydroisoquinoline (THIQ) alkaloids constitute a large and diverse class of bioactive natural products, with the parent compounds and related downstream biosynthetic secondary metabolites spanning thousands of isolated structures. Chemoenzymatic synthetic approaches toward the relevant THIQs rely on Pictet-Spenglerases such as norcoclaurine synthase (NCS), the scope of which is strictly limited to dopamine-related phenolic substrates. To overcome these limitations in the context of chemical synthesis, we herein report asymmetric Pictet-Spengler reactions of
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