Evidence map›Paper›PMID 35976097›Full record

ArticleeLife2022

Membrane-mediated dimerization potentiates PIP5K lipid kinase activity.

Scott D Hansen, Albert A Lee, Benjamin R Duewell, Jay T Groves

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Review
  3. Mimicking Cellular Membranes With Micropatterned Lipid Bilayers.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
  4. PIP4K attenuates PIP5K lipid kinase activity by disrupting membrane-mediated dimerization.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Distinct impact of PI(4)P flux on PI(4,5)PProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. OrthogonalApplied and environmental microbiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Nonlinear dynamics in phosphoinositide metabolism.Current opinion in cell biology · 2024
    Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Scott D HansenDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, United States.ORCID 0000-0001-7005-6200
Albert A LeeDepartment of Chemistry, University of California, Berkeley, Berkeley, United States.
Benjamin R DuewellDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, United States.
Jay T GrovesDepartment of Chemistry, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-3037-5220
QB3 · USUniversity of Oregon · US

Funding

Understand the metabolic fitness of naïve T cellsP01AI091580 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JEROEN ROOSE · 2011 to 2026
$31.1M
MOLECULAR BIOLOGY AND BIOPHYSICST32GM007759 · NIGMS · UNIVERSITY OF OREGON · PI NOLEN, BRADLEY J · 1985 to 2021
$8.5M
Self-organized membrane polarity of a phosphatidylinositol-based signaling systemF32GM111010 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI HANSEN, SCOTT DAVID · 2014 to 2015
$106k
NIAID NIH HHS P01 AI091580NIGMS NIH HHS F32 GM111010NIGMS NIH HHS T32 GM007759
6 · The paper itself

Abstract

The phosphatidylinositol 4-phosphate 5-kinase (PIP5K) family of lipid-modifying enzymes generate the majority of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P

Indexed as

PhosphatesPhosphotransferases (Alcohol Group Acceptor)Cell MembraneDimerizationPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsPhosphorylationPhosphatesPhosphatidylinositol 4,5-DiphosphatePhosphatidylinositolsPhosphotransferases (Alcohol Group Acceptor)biochemistrychemical biologydimerizationkinasemembranemolecular biophysicsphosphatidylinositol phosphate lipidsPI(4,5)P2PIP5Kstructural biology

Identifiers

PMID35976097
PMCPMC9470164
OpenAlexW4292092794

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.