Evidence map›Paper›PMID 35975982›Full record

ArticleACS applied materials & interfaces2022

Ytterbium Nanoparticle Contrast Agents for Conventional and Spectral Photon-Counting CT and Their Applications for Hydrogel Imaging.

Yuxi C Dong, Ananyaa Kumar, Derick N Rosario-Berríos, Salim Si-Mohamed, Jessica C Hsu, Lenitza M Nieves, Philippe Douek, Peter B Noël, David P Cormode

Open access · greenAbstract read
In one paragraph

Article in ACS applied materials & interfaces, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. K-Edge imaging using a clinical dual-source photon-counting CT system.Journal of applied clinical medical physics · 2026
    Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Brachytherapy at the nanoscale with protein functionalized and intrinsically radiolabeled [European journal of nuclear medicine and molecular imaging · 2024
    Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Yuxi C DongDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0001-7739-3795
Ananyaa KumarDepartment of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Derick N Rosario-BerríosDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.
Salim Si-MohamedCREATIS, CNRS UMR 5220, INSERM U1206, INSA, University Claude Bernard Lyon 1, F69621 Lyon, France.ORCID 0000-0003-0314-4010
Jessica C HsuDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-3599-2834
Lenitza M NievesDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-2241-1025
Philippe DouekCREATIS, CNRS UMR 5220, INSERM U1206, INSA, University Claude Bernard Lyon 1, F69621 Lyon, France.
Peter B NoëlDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-9671-6171
David P CormodeDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States.ORCID 0000-0002-8391-9500
University of Pennsylvania · USUniversité Claude Bernard Lyon 1 · FR

Funding

Nanoparticle contrast agents for earlier breast cancer detectionR01CA227142 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2018 to 2022
$2.5M
Renally clearable ytterbium nanoparticle contrast agents for spectral photon counting computed tomographyR21EB030373 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2021 to 2022
$447k
Tumor casting hydrogels for interventional radiology treatment of hepatocellular carcinomaR21EB029556 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI CORMODE, DAVID PETER · 2021 to 2022
$447k
NCI NIH HHS R01 CA227142NIBIB NIH HHS R21 EB029556NIBIB NIH HHS R21 EB030373
6 · The paper itself

Abstract

Significant work has been done to develop nanoparticle contrast agents for computed tomography (CT), with a focus on identifying safer and more effective formulations. Contrast agents for spectral photon-counting computed tomography (SPCCT), a fast-growing imaging modality derived from conventional CT, have also recently gained considerable attention. In this study, we explored the synthesis of ultrasmall ytterbium nanoparticles (YbNP) and demonstrated that, potentially, they can be used as conventional CT and SPCCT contrast agents. These nanoparticles were tested

Indexed as

Contrast MediaMetal NanoparticlesGoldHydrogelsPhantoms, ImagingPhotonsTomography, X-Ray ComputedYtterbiumContrast MediaGoldHydrogelsYtterbiumcomputed tomographycontrast agentshydrogelspectral photon-counting CTytterbium nanoparticles

Identifiers

PMID35975982
PMCPMC9513702
OpenAlexW4292262128

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.