Evidence map›Paper›PMID 35975974›Full record

ArticleEndocrine-related cancer2022

The immune cell infiltrate in the tumour microenvironment of phaeochromocytomas and paragangliomas.

N Tufton, R J Hearnden, D M Berney, W M Drake, L Parvanta, J P Chapple, S A Akker

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine-related cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06444607 (HEPHESTOS - Hereditary Pheochromocytoma Assessment of Tumour Immunologies), which is not on this map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06444607 recruitingnot on this mapstarted 2024, after this paper: background citation

HEPHESTOS - Hereditary Pheochromocytoma Assessment of Tumour Immunologies

TypeobservationalSponsorRadboud University Medical CenterRan2024 to 2029Enrolled200ConditionsPheochromocytoma, ParagangliomaArmsVenepuncture
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Prognosis and tumor microenvironment in pseudohypoxic pheochromocytoma/paraganglioma.Virchows Archiv : an international journal of pathology · 2025
    Article
  5. [Endothelial cells and fibroblasts mediate the microenvironmental regulatory network of carotid body paraganglioma].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  6. [Advance in HIF expression and immune microenvironment in pseudohypoxic HNPGL].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Review
  7. Review
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Review
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  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

N TuftonCentre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.ORCID 0000-0003-2382-9711
R J HearndenCentre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.ORCID 0000-0002-6721-6207
D M BerneyDepartment of Pathology, Royal London Hospital, Whitechapel, London, UK.
W M DrakeCentre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
L ParvantaDepartment of Endocrine Surgery, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK.
J P ChappleCentre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.
S A AkkerCentre for Endocrinology, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK.ORCID 0000-0003-3893-3116
Queen Mary University of London · GBSt Bartholomew's Hospital · GBRoyal London Hospital · GB

Funding

Cancer Research UK C16420/A18066
6 · The paper itself

Abstract

Emerging evidence suggests the composition of the tumour microenvironment (TME) correlates with clinical outcome and that each tumour type has a unique TME including a variable population of inflammatory cells. We performed immunohistochemistry on 65 phaeochromocytoma and paraganglioma (PPGL) tumour samples with 20 normal adrenal medulla samples for comparison. The immune cells assessed were macrophages, lymphocytes and neutrophils, and we compared the proportion of infiltration of these immune cells with clinical and histopathological factors. There was a higher proportion of immune cells in tumour tissue compared to non-neoplastic adrenal medulla tissue, with a predominance of macrophages. There was a higher proportion of M2:M1 macrophages and T-helper lymphocytes in aggressive tumours compared to indolent ones. For SDHB-associated tumours, there was a higher proportion of M2 macrophage infiltration, with higher M2:M1 in aggressive SDHB PPGLs compared to indolent tumours. These data demonstrate that immune cells do infiltrate the TME of PPGLs, confirming that PPGLs are immunologically active tumours. Differences in the TME of PPGLs were observed between aggressive and indolent tumours. These differences could potentially be exploited as an aid in predicting tumour behaviour.

Indexed as

Adrenal Gland NeoplasmsParagangliomaPheochromocytomaHumansImmunohistochemistryTumor Microenvironmentimmune cellslymphocytemacrophageparagangliomaphaeochromocytomatumour microenvironment

Identifiers

PMID35975974
PMCPMC9513653
OpenAlexW4292262245

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.