Evidence map›Paper›PMID 35975795›Full record

ReviewCardiology journal2023

Catheter-directed therapy to treat intermediateand high-risk pulmonary embolism: Personal experience and review of the literature.

Arkadiusz Pietrasik, Aleksandra Gasecka, Aleksander Kotulecki, Paulina Karolak, Aleksander Araszkiewicz, Szymon Darocha, Marcin Grabowski, Marcin Kurzyna

Open access · goldAbstract readReview
In one paragraph

Review in Cardiology journal, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Arkadiusz Pietrasik1st Chair and Department of Cardiology, Medical University of Warsaw, Poland. arekpietrasik@icloud.com.
Aleksandra Gasecka1st Chair and Department of Cardiology, Medical University of Warsaw, Poland.ORCID 0000-0001-5083-7587
Aleksander Kotulecki1st Chair and Department of Cardiology, Medical University of Warsaw, Poland.
Paulina Karolak1st Chair and Department of Cardiology, Medical University of Warsaw, Poland.
Aleksander Araszkiewicz1st Department of Cardiology, University of Medical Sciences, Poznan, Poland.
Szymon DarochaDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Center of Postgraduate Medical Education, European Health Center Otwock, Poland.ORCID 0000-0001-8298-9243
Marcin Grabowski1st Chair and Department of Cardiology, Medical University of Warsaw, Poland.
Marcin KurzynaDepartment of Pulmonary Circulation, Thromboembolic Diseases and Cardiology, Center of Postgraduate Medical Education, European Health Center Otwock, Poland.
Medical University of Warsaw · PLPoznan University of Medical Sciences · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pulmonary embolism (PE) is the third leading cause of cardiovascular death in the western world. Prompt recognition, risk stratification, and individualized treatment are crucial to improve outcomes in patients with PE. Anticoagulation alone is a sufficient therapeutic option in low-risk patients, whereas primary reperfusion with systemic thrombolysis (ST) is usually chosen in high-risk patients. The choice of treatment in intermediate-risk patients is complex and depends on the clinical presentation. Catheter-directed therapy (CDTh) includes all therapies delivered via a catheter placed in the branches of the pulmonary arteries directly into the thrombus. Because ST bears a high risk of major bleeding and numerous patients have contraindications to ST, CDTh is an alternative to ST in intermediate- and high-risk PE patients. CDTh includes local thrombolysis using low-dose alteplase, ultrasound-assisted thrombolysis, and mechanical fragmentation and aspiration of the thrombi, as well as their combinations. In this review article, we have summarized devices and technical details for CDTh, discussed the efficacy and safety of CDTh in comparison to ST in previous clinical trials, and outlined future research directions regarding CDTh, both based on the literature and our personal experience from the local PE Response Team of the Center for the Management of Pulmonary Embolism (CELZAT) in Warsaw.

Indexed as

Pulmonary EmbolismThrombolytic TherapyCathetersFibrinolytic AgentsHumansThrombectomyTreatment OutcomeFibrinolytic Agentscatheter-based therapyinterventional cardiologypulmonary embolismreview

Identifiers

PMID35975795
PMCPMC10287075
OpenAlexW4292289279

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.