Evidence map›Paper›PMID 35975640›Full record

ArticleGut and liver2022

Exploration of Potential Gut Microbiota-Derived Biomarkers to Predict the Success of Fecal Microbiota Transplantation in Ulcerative Colitis: A Prospective Cohort in Korea.

Gi-Ung Kang, Sowon Park, Yeongyun Jung, Jai J Jee, Min-Sueng Kim, Seungjun Lee, Dong-Woo Lee, Jae-Ho Shin, Hong Koh

Open access · diamondAbstract read
In one paragraph

Article in Gut and liver, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Fecal Microbiota Transplantation BeyondJournal of Korean medical science · 2026
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  12. Consumption ofInternational journal of molecular sciences · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Gi-Ung KangDepartment of Applied Biosciences, Kyungpook National University, Daegu, Korea.ORCID 0000-0003-3536-830X
Sowon ParkDepartment of Pediatrics, Severance Fecal Microbiota Transplantation Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0002-2498-8004
Yeongyun JungDepartment of Applied Biosciences, Kyungpook National University, Daegu, Korea.ORCID 0000-0002-4117-7369
Jai J JeeDepartment of Pediatrics, Severance Fecal Microbiota Transplantation Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0003-4836-3698
Min-Sueng KimDepartment of Applied Biosciences, Kyungpook National University, Daegu, Korea.ORCID 0000-0001-5281-8291
Seungjun LeeDepartment of Food Science and Nutrition, Pukyong National University, Busan, Korea.ORCID 0000-0002-2848-3521
Dong-Woo LeeDepartment of Biotechnology, Yonsei University, Seoul, Korea.ORCID 0000-0002-2272-8321
Jae-Ho ShinDepartment of Applied Biosciences, Kyungpook National University, Daegu, Korea.ORCID 0000-0001-6450-9787
Hong KohDepartment of Pediatrics, Severance Fecal Microbiota Transplantation Center, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.ORCID 0000-0002-3660-7483
Kyungpook National University · KRYonsei University · KRPukyong National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: Although fecal microbiota transplantation (FMT) has been proven as one of the promising treatments for patients with ulcerative colitis (UC), potential prognostic markers regarding the clinical outcomes of FMT remain elusive. Methods: We collected fecal samples of 10 participants undergoing FMT to treat UC and those from the corresponding donors. We categorized them into two groups: responders and nonresponders. Sequencing of the bacterial 16S rRNA gene was conducted on the samples to explore bacterial composition. Results: Analyzing the gut microbiota of patients who showed different outcomes in FMT presented a distinct microbial niche. Source tracking analysis showed the nonresponder group had a higher rate of preservation of donor microbiota, underscoring that engraftment degrees are not one of the major drivers for the success of FMT. At the phylum level, Bacteroidetes bacteria were significantly depleted (p<0.003), and three genera, including Conclusions: This study is the first to suggest the significance of indigenous microbiota of recipients as a critical factor. The result highlights that bacterial composition should be evaluated before FMT to select suitable patients and achieve better efficiency.

Indexed as

Colitis, UlcerativeGastrointestinal MicrobiomeBiomarkersFecal Microbiota TransplantationFecesHumansProspective StudiesRNA, Ribosomal, 16STreatment OutcomeBiomarkersRNA, Ribosomal, 16SFecal microbiota transplantationFecal microbiota transplantation outcomeMachine learningUlcerative colitis

Identifiers

PMID35975640
PMCPMC9474483
OpenAlexW4292316641

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.