Evidence map›Paper›PMID 35975635›Full record

ArticleBJPsych open2022

Pharmacogenomics: an opportunity for personalised psychotropic prescribing in adults with intellectual disabilities.

Bhathika Perera, Charles Steward, Ken Courtenay, Timothy Andrews, Rohit Shankar

Open access · goldAbstract read
In one paragraph

Article in BJPsych open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Bhathika PereraBarnet, Enfield and Haringey Mental Health NHS Trust, London, UK.ORCID https://orcid.org/0000-0001-9316-9312
Charles StewardCongenica Ltd, Cambridge, UK.
Ken CourtenayBarnet, Enfield and Haringey Mental Health NHS Trust, London, UK.
Timothy AndrewsOxford Health NHS Foundation Trust, Oxford, UK.
Rohit ShankarPeninsula School of Medicine, University of Plymouth, UK; and Cornwall Partnership NHS Foundation Trust, Truro, UK.ORCID https://orcid.org/0000-0002-1183-6933
Barnet Enfield and Haringey Mental Health Trust · GBCornwall Partnership NHS Foundation Trust · GBOxford Health NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is growing evidence for the use of pharmacogenomics in psychotropic prescribing. People with intellectual disabilities are disproportionately prescribed psychotropics and are at risk of polypharmacy. There is an urgent need for safeguards to prevent psychotropic overprescribing but it is equally crucial that this population is not left behind in such exciting initiatives. Understanding how genetic variations affect medications is a step towards personalised medicine. This may improve personalised prescribing for people with intellectual disabilities, especially given the high rate of psychiatric and behavioural problems in this population. Our editorial explores opportunities and challenges that pharmacogenomics offers for the challenges of polypharmacy and overprescribing of psychotropics in people with intellectual disabilities.

Indexed as

discriminationgeneticsIntellectual disabilitiespolypharmacypsychotropics

Identifiers

PMID35975635
PMCPMC9438475
OpenAlexW4292318680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.