ArticleEpilepsia2022
Significant improvements in SEIzure interVAL (time between seizure clusters) across time in patients treated with diazepam nasal spray as intermittent rescue therapy for seizure clusters.
Article in Epilepsia, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
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- Trial
- Safety of Diazepam Nasal Spray in Pediatric Patients With Developmental Epileptic Encephalopathies: Results From a Long-term Phase 3 Safety Study.Journal of child neurology · 2023Trial
- Benzodiazepines in Epilepsy: A US Perspective on Clinical Use, Pharmacology, Abuse Methods, and Public Health Considerations.Neurology and therapy · 2026Review
- Preclinical signal for a disease-modifying effect on seizure cluster severity with intermittent diazepam treatment.Epilepsia · 2026Article
- Seizure Clusters: Current Concepts in Definition and Treatment.Journal of clinical medicine · 2026Review
- Potential for Therapeutic Alteration of the Underlying Biology of Epilepsy.Biomedicines · 2025Review
- Benzodiazepine rescue medication administration for seizure clusters: Real-world retrospective outcomes.Epilepsia · 2025Article
- Development of a novel dosing paradigm to model diazepam rescue therapy in preclinical seizure and epilepsy models.Epilepsia open · 2024Article
- Safety and effectiveness of diazepam nasal spray in male and female patients: Post hoc analysis of data from a phase 3 safety study.Epilepsia open · 2024Article
- Rapid Rescue Treatment with Diazepam Nasal Spray Leads to Faster Seizure Cluster Termination in Epilepsy: An Exploratory Post Hoc Cohort Analysis.Neurology and therapy · 2024Article
- Benzodiazepines for the Treatment of Seizure Clusters.CNS drugs · 2024Review
- Intracerebral electrographic activity following a single dose of diazepam nasal spray: A pilot study.Epilepsia open · 2024Article
- Taking a Newer, Faster, Intranasal Route: A Narrative Review of Transitioning to a Less-Invasive Rescue Treatment for Seizure Clusters.Patient preference and adherence · 2024Review
- Analyses of patients who self-administered diazepam nasal spray for acute treatment of seizure clusters.Epilepsy & behavior reports · 2024Article
- Treatment of Seizure Clusters in Epilepsy: A Narrative Review on Rescue Therapies.Neurology and therapy · 2023Review
- Article
- Safety and effectiveness of diazepam nasal spray in patients with Rett syndrome and seizure clusters:Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIntermittent rescue therapy may be used for seizure clusters, which are clinical emergencies that may persist ≥24 h and increase risk of status epilepticus, emergency room visits, and reduced quality of life for patients with epilepsy. Beyond effectiveness for aborting seizure clusters, no data exist on how intermittent rescue therapy may impact the long-term natural course of seizure clusters. This novel analysis explores SEIzure interVAL (SEIVAL; time between seizure clusters) in patients from a long-term safety study of diazepam nasal spray (Valtoco) to assess SEIVAL changes with intermittent rescue therapy across time.
methodsPatients were aged 6-65 years. Age- and weight-based doses of diazepam nasal spray were administered during a 12-month treatment period with an optional follow-up period. SEIVAL was evaluated in patients receiving two or more doses of diazepam nasal spray using 90-day periods.
resultsOf 163 treated patients, 151 had one or more SEIVALs. One hundred twenty had SEIVALs in Period 1 and one or more other periods. An increase in SEIVAL was noted from Period 1 compared with all subsequent periods (p ≤ .001). A consistent cohort (n = 76) had one or more SEIVALs in each of Periods 1-4 (360 days); mean SEIVALs increased significantly (p < .01) from 12.2 days (Period 1) to 25.7 days (Period 4). Similar SEIVAL patterns occurred when repeat doses within a seizure cluster were eliminated and irrespective of age group, treatment duration, and change to concomitant medications. In adults, Quality of Life in Epilepsy scores were maintained with increased SEIVALs. SIGNIFICANCE: Across 12 months, increases in SEIVAL were demonstrated in patients using diazepam nasal spray for seizure cluster treatment in a phase 3 safety study. Increased time between seizure clusters may reflect a previously unrecognized beneficial effect of intermittent rescue therapy. These results generate a range of biological and behavioral hypotheses and warrant exploration of the impact of intermittent rescue therapy.
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