ArticleJournal of clinical and translational research2022
Multifocal diffuse large cell neuroendocrine carcinoma of the colon.
Article in Journal of clinical and translational research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed, 2 citations in OpenAlex.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
Background: Large cell neuroendocrine carcinomas (LCNEC) of the colon are an extremely rare and aggressive type of colorectal cancer. While multifocality is more frequently seen in small intestine NECs, no cases of multifocal NEC of the colon have been reported before. Aim: A 69-year-old male patient presented with abdominal pain. Colonoscopy revealed a necrotic-polypoid mass in the sigmoid colon and the biopsy result was reported as malignant epithelial tumor. Laparoscopic anterior resection was performed with the preliminary diagnosis of colon adenocarcinoma. Histopathological examination revealed three polypoid tumors, the largest of which was 4 cm, in the sigmoid colon. Immunohistochemical examination showed positivity for synaptophysin, chromogranin, and CDX2. High Ki67 proliferation index, high mitosis, and widespread p53 expression were observed in all tumors. With these findings, a diagnosis of multifocal large cell NEC was made. To the best of our knowledge, this is the first report describing a case of multifocal large cell NEC of the colon. Relevance for Patients: LCNECs of the colon are very aggressive. Here, we report for the first time a case of multifocal LCNEC. In a short period of 1 month after the surgery, new widespread metastases were detected in the liver. Therefore, these tumors should be followed more closely than usual for early treatment.
Indexed as
Identifiers
35975187PMC9373722W4285175336What OpenQuestion holds
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