Evidence map›Paper›PMID 35974881›Full record

ArticleGastro hep advances2022

A Prediction Model Incorporating Peripheral Eosinopenia as a Novel Risk Factor for Death After Hospitalization for

Ying Wang, Hojjat Salmasian, Aaron Schluger, Angela Gomez-Simmonds, Alexa Choy, Jianhua Li, Jordan E Axelrad, Daniel E Freedberg

Open access · goldAbstract read
In one paragraph

Article in Gastro hep advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Influence of COVID-19 on Clinical Outcomes ofAntibiotics (Basel, Switzerland) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Ying WangDepartment of Medicine, Rutgers Robert Wood Johnson University Hospital, New Brunswick, New Jersey.
Hojjat SalmasianDivision of General Internal Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
Aaron SchlugerDepartment of Medicine, Westchester Medical Center, Valhalla, New York.
Angela Gomez-SimmondsDepartment of Medicine, Columbia University Medical Center, New York, New York.
Alexa ChoyDepartment of Medicine, Columbia University Medical Center, New York, New York.
Jianhua LiDepartment of Medicine, Columbia University Medical Center, New York, New York.
Jordan E AxelradDepartment of Medicine, NYU Langone Health, New York, New York.
Daniel E FreedbergDepartment of Medicine, Columbia University Medical Center, New York, New York.
Columbia University Irving Medical Center · USBrigham and Women's Hospital · USNYU Langone Health · USRutgers, The State University of New Jersey · USWestchester Medical Center · US

Funding

Loss of Gastrointestinal Colonization Resistance and Antibiotic-Resistant Infections in the Intensive Care UnitK23DK111847 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREEDBERG, DANIEL E. · 2017 to 2020
$608k
NIDDK NIH HHS K23 DK111847
6 · The paper itself

Abstract

BACKGROUND AND

aims

methodsEosinopenia was defined as 0 eosinophils/

resultsThere were 4518 unique hospitalized adults with CDI included (2142 in the derivation cohort and 2376 in the validation cohort). All-cause 30-day mortality was 9% and 10% in the cohorts. In the validation cohort, the factors most strongly associated with death were eosinopenia (adjusted odds ratio [aOR] 2.49, 95% confidence interval [CI] 1.77-3.50), albumin <3 g/dL (aOR 3.26, 95% CI 2.13-3.49), and creatinine >1.5 mg/dL (aOR 2.55, 95% CI 1.86-3.49). A 6-variable clinical prediction model was developed that improved on existing classification schemes for CDI severity (area under the receiver operating characteristic curve of 0.75 vs 0.68).

conclusionAmong adults hospitalized with CDI, peripheral eosinopenia was associated with increased risk of all-cause 30-day mortality. A prediction model incorporating peripheral eosinopenia was developed to improve care for hospitalized patients with CDI through risk stratification.

Indexed as

Clostridioides difficile Infection (CDI)Peripheral EosinopeniaPrediction Model for Clostridioides difficile Infection Mortality

Identifiers

PMID35974881
PMCPMC9377641
OpenAlexW3210331284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.