Evidence map›Paper›PMID 35974701›Full record

ReviewExperimental biology and medicine (Maywood, N.J.)2022

Human stem cell-derived neurons and neural circuitry therapeutics: Next frontier in spinal cord injury repair.

Maria Belen Paredes-Espinosa, Janet L Paluh

Abstract readReview
In one paragraph

Review in Experimental biology and medicine (Maywood, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Targeting Arterial Dysfunction in Cardiovascular Disease Using Stem Cell-Based Therapies.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Review
  3. Article
  4. Review
  5. Spinal cord injury: molecular mechanisms and therapeutic interventions.Signal transduction and targeted therapy · 2023
    Review
  6. The therapeutic bionanoscience interface.Experimental biology and medicine (Maywood, N.J.) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Maria Belen Paredes-EspinosaNanobioscience Constellation, College of Nanoscale Science and Engineering, State University of New York Polytechnic Institute, Albany, NY 12203, USA.ORCID 0000-0002-7249-5140
Janet L PaluhNanobioscience Constellation, College of Nanoscale Science and Engineering, State University of New York Polytechnic Institute, Albany, NY 12203, USA.ORCID 0000-0002-5988-6075

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) remains a life-altering event that devastates those injured and the families that support them. Numerous laboratories are engaged in preclinical and clinical trials to repair the injured spinal cord with stem cell-derived therapeutics. A new developmental paradigm reveals early bifurcation of brain or trunk neurons in mammals via neuromesodermal progenitors (NMPs) relevant to therapies requiring homotypic spinal cord neural populations. Human-induced pluripotent stem cell (hiPSC) NMP-derived spinal motor neurons generated

Indexed as

Neural Stem CellsSpinal Cord InjuriesAnimalsCell DifferentiationHumansMammalsMotor NeuronsRatsSpinal CordStem Cell Transplantationbioengineeringclinical trialgastruloidhuman-induced pluripotent stem cell spinal motor neuron subtypemicroenvironmentNeuromesodermal progenitor

Identifiers

PMID35974701
PMCPMC9837306

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.