Evidence map›Paper›PMID 35974467›Full record

Trial reportSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)2022

Efficacy of a novel microneedle patch for rejuvenation of the nasolabial fold.

Ungsuthorn Pruettijarai, Jitlada Meephansan, Ornicha Prapapan, Purit Pureesrisak, Punyaphat Sirithanabadeekul, Kittipong Tantisantisom, Sattra Thongma, Yossawat Rayanasukha, Punyanuch Adulyaritthikul, Paisan Khanchaitit

Open access · hybridAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Efficacy of a novel microneedle patch for rejuvenation of the nasolabial fold.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2022
    Trial
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Ungsuthorn PruettijaraiDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Jitlada MeephansanDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Ornicha PrapapanDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Purit PureesrisakDivision of Dermatology, Department of Medicine, Rajavithi Hospital, Ministry of Public Health, Bangkok, Thailand.
Punyaphat SirithanabadeekulDivision of Dermatology, Chulabhorn International College of Medicine, Thammasat University, Pathum Thani, Thailand.
Kittipong TantisantisomNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Sattra ThongmaNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Yossawat RayanasukhaNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Punyanuch AdulyaritthikulNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
Paisan KhanchaititNational Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA), Pathum Thani, Thailand.
National Nanotechnology Center · THThammasat University · THMinistry of Public Health · THNational Science and Technology Development Agency · TH

Funding

Chulabhorn International College of Medicine F1/2564Thammasat University Research Unit in the development of an LED microneedle patch for aesthetic and skin diseases
6 · The paper itself

Abstract

backgroundSkin rejuvenation plays a significant role in the esthetic medicine market. Microneedle patches have been developed for a wide range of applications based on the principles of transdermal drug delivery; however, clinical trials of microneedle patches for skin rejuvenation remain limited.

aimsThis study was conducted to examine the efficacy of microneedle patches for improving nasolabial folds.

methodsA total of 23 Thai women completed this prospective clinical trial. The participants were treated according to a split-face design, with application of microneedle patch plus 1.8% hyaluronic acid solution to the right nasolabial fold and microneedle patch alone to the left nasolabial fold. The treatments were applied to the nasolabial fold for 8 weeks. The test areas were measured before treatment and at 2, 4, 8, 12, and 16 weeks after the use of the test product.

resultsCombination treatment using the microneedle patch plus hyaluronic acid solution and use of the microneedle patch alone both significantly improved the Merz esthetic scales for nasolabial folds. Measurement of the nasolabial fold showed an improvement in the two groups, with no significant differences between the groups. No adverse effects were reported during the study period.

conclusionsApplication of a microneedle patch with 1.8% hyaluronic acid solution or a microneedle patch alone were both effective treatments for improving facial wrinkles in the nasolabial folds.

Indexed as

Cosmetic TechniquesSkin AgingAdministration, CutaneousFemaleHumansHyaluronic AcidNasolabial FoldRejuvenationTreatment OutcomeHyaluronic Acidaginghyaluronic acidmicroneedle patchrejuvenationwrinkle

Identifiers

PMID35974467
PMCPMC9907590
OpenAlexW4292295252

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.