Evidence map›Paper›PMID 35974429›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Evolution and Transmission of Cefiderocol-Resistant Acinetobacter baumannii During an Outbreak in the Burn Intensive Care Unit.

Steven M Smoke, Alison Brophy, Samuel Reveron, Alina Iovleva, Ellen G Kline, Michael Marano, Lincoln P Miller, Ryan K Shields

Abstract read
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Article
  2. High-Resolution Genomic Surveillance of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Antimicrobial agents and chemotherapy · 2025
    Review
  10. Review
  11. Article
  12. ComparativeJAC-antimicrobial resistance · 2025
    Article
  13. Review
  14. Review
  15. Article
  16. Antimicrobial agents and chemotherapy · 2024
    Article
  17. Article
  18. Article
  19. Challenges Facing Two Outbreaks of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2024
    Article
  20. Treatment-emergent cefiderocol resistance in carbapenem-resistantAntimicrobial agents and chemotherapy · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Steven M SmokeDepartment of Pharmacy, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.ORCID 0000-0003-4847-3432
Alison BrophyDepartment of Pharmacy, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Samuel ReveronDepartment of Pharmacy, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Alina IovlevaDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Ellen G KlineDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Michael MaranoDepartment of Surgery, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Lincoln P MillerDepartment of Medicine, Cooperman Barnabas Medical Center, Livingston, New Jersey, USA.
Ryan K ShieldsDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Institutional Career Development CoreKL2TR001856 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, KRISTIN N, RUBIO, DORIS M · 2016 to 2025
$13.8M
Use of site-specific pharmacokinetics to optimize antibiotic combinations and prevent the emergence of resistance against CRER21AI151363 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2021 to 2022
$431k
Characterization and suppression of resistance to new CRE agentsR03AI144636 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2019 to 2020
$157k
NIAID NIH HHS R03 AI144636NIAID NIH HHS R21 AI151363NIH HHS 2KL2TR001856-06
6 · The paper itself

Abstract

We report on 11 critically ill burn patients treated with cefiderocol for carbapenem-resistant Acinetobacter baumannii infections. Clinical success was achieved in 36% and complicated by treatment-emergent resistance and interpatient transmission of cefiderocol-resistant A. baumannii. Resistant isolates harbored disrupted pirA and piuA genes that were not disrupted among susceptible isolates.

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsCefiderocolDisease OutbreaksDrug Resistance, Multiple, BacterialHumansIntensive Care UnitsMicrobial Sensitivity TestsAnti-Bacterial AgentsCefiderocolantibiotic resistanceburncarbapenem-resistant Acinetobacter baumanniicefiderocolwhole-genome sequencing

Identifiers

PMID35974429
PMCPMC10169418

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.