Evidence map›Paper›PMID 35974399›Full record

ArticleActa neuropathologica communications2022

Pathological changes induced by Alzheimer's brain inoculation in amyloid-beta plaque-bearing mice.

Suzanne Lam, Anne-Sophie Hérard, Susana Boluda, Fanny Petit, Sabiha Eddarkaoui, Karine Cambon, Brainbank Neuro-CEB Neuropathology Network, Jean-Luc Picq, Luc Buée, Charles Duyckaerts and 2 more

Open access · goldAbstract read
In one paragraph

Article in Acta neuropathologica communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 21 citations in OpenAlex.

  1. PET imaging of alpha-synuclein: from radiotracer design through in vitro and in vivo translation.European journal of nuclear medicine and molecular imaging · 2026
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  16. Protein Interactome of Amyloid-β as a Therapeutic Target.Pharmaceuticals (Basel, Switzerland) · 2023
    Review
  17. Article
  18. Microglia and Alzheimer's Disease.International journal of molecular sciences · 2022
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Suzanne LamCEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
Anne-Sophie HérardCEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
Susana BoludaICM Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France.
Fanny PetitCEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
Sabiha EddarkaouiInserm, CHU-Lille, Lille Neuroscience & Cognition, Alzheimer & Tauopathies, LabEx DISTALZ, Université de Lille, Rue Polonovski, 59045, Lille, France.
Karine CambonCEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
Brainbank Neuro-CEB Neuropathology Network
Jean-Luc PicqCEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France.
Luc BuéeInserm, CHU-Lille, Lille Neuroscience & Cognition, Alzheimer & Tauopathies, LabEx DISTALZ, Université de Lille, Rue Polonovski, 59045, Lille, France.
Charles DuyckaertsICM Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France.
Stéphane HaïkICM Institut du Cerveau et de la Moelle épinière, CNRS UMR7225, INSERM U1127, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris, France.
Marc DhenainCEA, CNRS, Laboratoire des Maladies Neurodégénératives, MIRCen, Université Paris-Saclay, 18 Route du Panorama, 92265, Fontenay-aux-Roses, France. Marc.Dhenain@cnrs.fr.ORCID 0000-0001-8804-4101
Centre National de la Recherche Scientifique · FRLaboratoire Cognitions Humaine et Artificielle · FRHospices Civils de Lyon · FRInserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is characterized by intracerebral accumulations of extracellular amyloid-β (Aβ) plaques and intracellular tau pathology that spread in the brain. Three types of tau lesions occur in the form of neuropil threads, neurofibrillary tangles, and neuritic plaques i.e. tau aggregates within neurites surrounding Aβ deposits. The cascade of events linking these lesions and synaptic or memory impairments are still debated. Intracerebral infusion of human AD brain extracts in Aβ plaque-bearing mice that do not overexpress pathological tau proteins induces tau pathologies following heterotopic seeding of mouse tau protein. There is however little information regarding the downstream events including synaptic or cognitive repercussions of tau pathology induction in these models. In the present study, human AD brain extracts (AD

Indexed as

Alzheimer DiseasePlaque, AmyloidAmyloid beta-PeptidesAnimalsBrainHumansMiceNeurofibrillary Tanglestau ProteinsAmyloid beta-Peptidestau ProteinsAlzheimer's diseaseAmyloid-βMemoryMicrogliaSynapsesTauTransmission

Identifiers

PMID35974399
PMCPMC9380345
OpenAlexW4292184383

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.