Observational studyReproductive biology and endocrinology : RB&E2022
Usage and cost-effectiveness of elective oocyte freezing: a retrospective observational study.
Observational study in Reproductive biology and endocrinology : RB&E, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Socio-demographic profiles, motivations and perspectives of women undergoing publicly funded elective fertility preservation: a nationwide multicenter study in France.Journal of ovarian research · 2026Observational
- Gynecologic and Reproductive Health in Patients with Sickle Cell Disease: Underrecognized Challenges and Care Management Opportunities.Journal of clinical medicine · 2026Review
- Effect of cryopreservation duration on pregnancy outcomes in embryos: a systematic review and meta-analysis.Human reproduction open · 2026Review
- Planned Oocyte Cryopreservation Following the 2021 French Bioethics Law: Women's Characteristics and Early Clinical Outcomes From a Single-Center Observational Study.Journal of pregnancy · 2026Observational
- Nesting the Eggs on Another Day: Social Egg Freezing.Journal of obstetrics and gynaecology of India · 2025Review
- Factors affecting family planning among general surgery trainees.BMC medical education · 2025Article
- Machine learning algorithms in constructing prediction models for assisted reproductive technology (ART) related live birth outcomes.Scientific reports · 2024Article
- [Experiences of Unmarried Women Undergoing Planned Oocyte Cryopreservation].Journal of Korean Academy of Nursing · 2024Article
- Female fertility preservation for family planning: a position statement of the Italian Society of Fertility and Sterility and Reproductive Medicine (SIFES-MR).Journal of assisted reproduction and genetics · 2024Article
- Outcomes of Fertility Preservation for Female Cancer Patients in a Single Tertiary Center.Yonsei medical journal · 2023Article
- Outcomes of Social Egg Freezing: A Cohort Study and a Comprehensive Literature Review.Journal of clinical medicine · 2023Article
- The importance of social oocyte cryopreservation in supporting local municipalities: A prospective study.Women's health (London, England)Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThe previous model-based cost-effectiveness analyses regarding elective oocyte cryopreservation remained debatable, while the usage rate may influence the cost per live birth. The aim of this study is to disclose the usage and cost-effectiveness of the planned cryopreserved oocytes after oocyte thawing in real-world situations.
methodsThis was a retrospective single-center observational study. Women who electively cryopreserved oocytes and returned to thaw the oocytes were categorized as thawed group. The oocytes were fertilized at our center and the sperm samples for each individual was retrieved from their respective husbands. Clinical outcomes were traced and the cumulative live birth rate per thawed case was calculated. The costs from oocyte freezing cycles to oocyte thawing, and embryo transfer cycles were accordingly estimated. The cumulative cost per live birth was defined by the cumulative cost divided by the live births per thawed case.
resultsWe recruited 645 women with 840 oocyte retrieval cycles for elective oocyte freezing from November 2002 to December 2020. The overall usage rate was 8.4% (54/645). After the storage duration exceeded ten years, the probabilities of thawing oocytes were 10.6%, 26.6%, and 12.7% from women who cryopreserved their oocytes at the age ≤ 35 years, 36-39 years, and ≥ 40 years, respectively (P = 0.304). Among women who thawed their oocytes, 31.5% (17/54) of women achieved at least one live birth. For the age groups of ≤ 35 years, 36-39 years, and ≥ 40 years, the cumulative live birth rates per thawed case were 63.6%, 42.3%, and 17.6%, respectively (P = 0.045), and the cumulative costs for one live birth were $11,704, $17,189, and $35,642, respectively (P < 0.001).
conclusionsThe overall usage rate was 8.4% in our cohort. The cumulative live birth rate was greatest in the youngest group and the cumulative cost per live birth was highest in the oldest group, which was threefold greater than that in the group aged ≤ 35 years. The findings added to the limited evidence of the usage rate in real-world situations, which could hopefully aid future analysis and decision-making in public health policy and for women willing to preserve fertility.
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