Evidence map›Paper›PMID 35974320›Full record

ArticleBMC musculoskeletal disorders2022

Early menopause and weight loss are significant factors associated with risk of future fracture in middle-aged women.

Louise Moberg, Viktor Hamrefors, Artur Fedorowski, Cecilia Rogmark

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04151732 (Factors Associated With Future Fractures in Middle-aged Men and Women. A Prospective Cohort Study From Malmö Dietary Cancer Cohort), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04151732 completednot on this map

Factors Associated With Future Fractures in Middle-aged Men and Women. A Prospective Cohort Study From Malmö Dietary Cancer Cohort

TypeobservationalSponsorLund UniversityRan2018 to 2020Enrolled30,351ConditionsFractures, Bone, Fragility, Life StyleArmsPhysical activity, alcohol, tobacco, Hormonal factors, Cardiovascular disease, Anthropometric measures
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Louise MobergDepartment of Obstetrics and Gynaecology, Skåne University Hospital, Klinikgatan 12, 221 85, Lund, Sweden. louise.moberg@med.lu.se.ORCID https://orcid.org/0000-0002-5120-819X
Viktor HamreforsDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-8475-0866
Artur FedorowskiDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-5352-6327
Cecilia RogmarkDepartment of Clinical Sciences, Lund University, Malmö, Sweden.ORCID https://orcid.org/0000-0002-6556-4320
Lund University · SEKarolinska University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo identify factors related to reproductive history and weight change associated with first incident fracture in middle-aged women.

methodsIn total, 18,326 women from the Malmö Diet and Cancer study were included in this prospective population-based cohort study. Participants were included 1991-1996 and followed to 2016. Using data from the National Patient Registry, linked with every participants' unique personal identification number, any first fracture affecting spine, thoracic cage, upper and lower extremities was identified. The association of baseline factors with incident fracture risk was analyzed using Cox regression models.

resultsFor participating women, median age 56.0 years, the multivariable Cox regression analysis observed that early menopause (40-44 years) (hazard ratio (HR) 1.14, 95% confidence interval (CI) 1.03-1.27) but not premature menopause < 40 years (HR 1.06, 95% CI 0.91-1.24) was associated with future fracture risk. Self-reported weight loss since age 20 was also associated with future fracture risk (HR 1.39, 95% CI 1.17-1.65) whereas a daily alcohol consumption in the third quartile (5.36-11.42 g/day) compared to the lowest quartile (0-0.80 g/day) was associated with decreased future fracture risk (HR 0.88, 95% CI 0.81-0.96). The multivariable Cox regression analysis also observed that increasing age and weight at baseline, current smoking, a positive history of previous fracture and family history of fractures were associated with increased fracture risk whereas an increasing BMI was associated with a decreased fracture risk. No association to parity or period of lactation was observed nor ever-use of oral contraceptives and menopausal hormone therapy.

conclusionThis study shows that early menopause between 40 to 45 years and self-reported weight loss since age of 20 are relevant factors associated with increased fracture risk in middle-aged women. These factors were independent of traditional predictors of fracture risk among women and may be considered in preventive initiatives.

trial registrationClinicaltrials.gov with identifier: NCT04151732, since Nov 5th 2018.

Indexed as

Fractures, BoneMenopauseAdultCohort StudiesFemaleHumansMiddle AgedPregnancyProspective StudiesRisk FactorsWeight LossYoung AdultAgingFracture preventionGeneral population studiesMenopauseWeight change

Identifiers

PMID35974320
PMCPMC9380294
OpenAlexW4291824992

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.