ArticleMolecular psychiatry2022
Genome-wide meta-analyses reveal novel loci for verbal short-term memory and learning.
Open access · hybridAbstract read
In one paragraph
Article in Molecular psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of BACE2 polymorphisms on verbal memory in the general population.European archives of psychiatry and clinical neuroscience · 2026Article
- Genetically linked brain imaging markers of memory decline in aging and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Neuronal and glial networks interact with traumatic brain injury to modulate cognition in ABCD study.NPJ systems biology and applications · 2026Article
- Prediction of Episodic Memory With Multiomics Scores.Biological psychiatry global open science · 2026Article
- Genome-wide association study identifies novel variants in olfactory, vitamin A, vitamin B, and cadherin pathways associated with learning and memory.Scientific reports · 2025Article
- Human iPSC-Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Topoisomerase 3b facilitates piRNA biogenesis to promote transposon silencing and germ cell development.Cell reports · 2025Article
- A self-supervised learning framework for discovering cortical folding patterns under genetic influence: Application to the Anterior Cingulate Cortex.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Charting the shared genetic architecture of Alzheimer's disease, cognition, and educational attainment, and associations with brain development.Neurobiology of disease · 2024Article
- Longitudinal change in memory performance as a strong endophenotype for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity.Progress in neurobiology · 2024Article
- The ROSMAP project: aging and neurodegenerative diseases through omic sciences.Frontiers in neuroinformatics · 2024Review
- The Alzheimer's Disease Neuroimaging Initiative in the era of Alzheimer's disease treatment: A review of ADNI studies from 2021 to 2022.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Review
- Article
- Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity.Research square · 2023Article
Corrections and comments
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Authors and funding
123 authors at 20 institutions in 13 countries.
Jari LahtiDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland. jari.lahti@helsinki.fi.ORCID http://orcid.org/0000-0002-4310-5297
Samuli TuominenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-1879-0739
Qiong YangDepartment of Biostatistics, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3658-1375
Giulio PergolaLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-9193-1841
Shahzad AhmadDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-8658-3790
Najaf AminDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Nicola J ArmstrongDepartment of Mathematics and Statistics, Murdoch University, Murdoch, WA, Australia.
Alexa BeiserDepartment of Biostatistics, Boston University, Boston, MA, USA.
Katharina BeyDepartment of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-3409-1110
Eric BoerwinkleHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
Jan BresslerHuman Genetics Center, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0001-6578-4772
Archie CampbellCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-0198-5078
Harry CampbellCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Qiang ChenLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Janie CorleyDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-7551-1871
Simon R CoxDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-4036-3642
Gail DaviesDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0003-1120-7026
Philip L De JagerCenter for Translational and Computational Neuroimmunology, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-8057-2505
Eske M DerksTranslational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-6292-6883
Jessica D FaulSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Annette L FitzpatrickDepartment of Family Medicine, University of Washington, Seattle, WA, USA.
Alison E FohnerDepartment of Epidemiology, University of Washington, Seattle, WA, USA.
Ian FordRobertson Center for Biostatistics, University of Glasgow, Glasgow, UK.
Myriam FornageMcGovern Medical School, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID http://orcid.org/0000-0003-0677-8158
Zachary GerringTranslational Neurogenomics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-2445-1266
Hans J GrabeDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-3684-4208
Francine GrodsteinChanning Laboratory, Brigham and Women's Hospital, Boston, MA, USA.
Vilmundur GudnasonIcelandic Heart Assocation, Kopavogur, Iceland.
Eleanor SimonsickTranslational Gerontology Branch, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA.
Elizabeth G HollidaySchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.
Peter K JoshiCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-6361-5059
Eero KajantieNational Institute for Health and Welfare, Helsinki and Oulu, Oulu, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-3716-2455
Pauliina KarellInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Luca KleineidamGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Maria J KnolDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-3597-1531
Nicole A KochanCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
John B KwokBrain and Mind Centre, The University of Sydney, Sydney, NSW, Australia.
Markus LeberDepartment of Psychiatry, University of Cologne, Cologne, Germany.
Max LamPsychiatry Research, Zucker Hillside Hospital, Glen Oaks, NY, USA.
Teresa LeeCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Shuo LiDepartment of Biostatistics, Boston University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-2331-2448
Anu LoukolaHelsinki Biobank, University of Helsinki Central Hospital, Helsinki, Finland.
Tobias LuckDepartment of Economic and Social Sciences & Institute of Social Medicine, Rehabilitation Sciences and Healthcare Research, University of Applied Sciences Nordhausen, Nordhausen, Germany.ORCID http://orcid.org/0000-0001-7551-4397
Riccardo E MarioniCentre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
Karen A MatherCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-4143-8941
Sarah MedlandQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0003-1382-380X
Saira S MirzaDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Mike A NallsLaboratory of Neurogenetics, National Institute on Aging, Bethesda, MD, USA.
Kwangsik NhoCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Adrienne O'DonnellDepartment of Biostatistics, Boston University, Boston, MA, USA.
Christopher OldmeadowClinical Research Design, IT and Statistical Support Unit, Hunter Medical Research Institute, New Lambton, NSW, Australia.
Jodie PainterQIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0002-4992-2458
Alison PattieDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Simone ReppermundCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Shannon L RisacherCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.
Richard J RoseDepartment of Psychological & Brain Sciences, Indiana University Bloomington, Bloomington, IN, USA.
Vijay SadashivaiahLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Markus ScholzInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0002-4059-1779
Claudia L SatizabalFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0002-1115-4430
Peter W SchofieldNeuropsychiatry Service, Hunter New England Local Health District, Charlestown, NSW, Australia.
Katharina E SchrautCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0001-7724-3404
Jeannette SiminoDepartment of Data Science, University of Mississippi Medical Center, Jackson, MS, USA.
Albert V SmithIcelandic Heart Assocation, Kopavogur, Iceland.
Jennifer A SmithDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-3575-5468
David J StottInstitute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
Ida SurakkaDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Alexander TeumerInstitute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-8309-094X
Anbupalam ThalamuthuCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
Stella TrompetSection of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0001-5006-0528
Stephen T TurnerDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Sven J van der LeeDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.
Arno VillringerMax Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany.ORCID http://orcid.org/0000-0003-2604-2404
Uwe VölkerInterfaculty Institute for Genetics and Functional Genomics, Department Functional Genomics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0002-5689-3448
Robert S WilsonRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Katharina WittfeldDepartment of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-4383-5043
Eero VuoksimaaInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.
Rui XiaInstitute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX, USA.
Kristine YaffeDepartment of Psychiatry, University of California, San Francisco, CA, USA.
Lei YuRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Habil ZareDepartment of Cell Systems & Anatomy, The University of Texas Health Science Center, San Antonio, TX, USA.ORCID http://orcid.org/0000-0001-5902-6238
Wei ZhaoDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0001-7388-0692
David AmesNational Ageing Research Institute, Parkville, Melbourne, VIC, Australia.
John AttiaSchool of Medicine and Public Health, University of Newcastle, Callaghan, NSW, Australia.ORCID http://orcid.org/0000-0001-9800-1308
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA.
Henry BrodatyCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0001-9487-6617
Daniel I ChasmanDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0003-3357-0862
Aaron L GoldmanLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Caroline HaywardMRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-9405-9550
M Arfan IkramDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0003-0372-8585
J Wouter JukemaDepartment of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.ORCID http://orcid.org/0000-0002-3246-8359
Sharon L R KardiaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, USA.
Todd LenczHofstra Northwell School of Medicine, Hempstead, NY, USA.ORCID http://orcid.org/0000-0001-8586-338X
Markus LoefflerInstitute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany.
Venkata S MattayLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Aarno PalotieInstitute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland.ORCID http://orcid.org/0000-0002-2527-5874
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7278-2190
Alfredo RamirezDepartment for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany.ORCID http://orcid.org/0000-0003-4991-763X
Paul M RidkerDivision of Preventive Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4321-6090
Perminder S SachdevCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-9595-3220
Andrew J SaykinCenter for Neuroimaging, Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA.ORCID http://orcid.org/0000-0002-1376-8532
Martin SchererInstitute of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Peter R SchofieldSchool of Medical Sciences, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0003-2967-9662
Stephen SidneyKaiser Permanente Northern California, Division of Research, Oakland, CA, USA.
John M StarrDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.
Julian TrollorCentre for Healthy Brain Ageing (CHeBA), School of Psychiatry, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.ORCID http://orcid.org/0000-0002-7685-2977
William UlrichLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.
Michael WagnerGerman Center for Neurodegenerative Diseases, Bonn, Germany.
David R WeirSurvey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-1661-2402
James F WilsonCentre for Global Health Research, Usher Institute, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0001-5751-9178
Margaret J WrightQueensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia.ORCID http://orcid.org/0000-0001-7133-4970
Daniel R WeinbergerLieber Institute for Brain Development, Johns Hopkins Medical Campus, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-2409-2969
Stephanie DebetteInserm, Bordeaux Population Health Research Center, team VINTAGE, UMR 1219, University of Bordeaux, Bordeaux, France.ORCID http://orcid.org/0000-0001-8675-7968
Johan G ErikssonFolkhälsan Research Center, Helsinki, Finland.
Thomas H MosleyDepartment of Medicine, Division of Geriatrics, University of Mississippi Medical Center, Jackson, MS, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3238-7612
Cornelia M van DuijnDepartment of Epidemiology, Erasmus MC University Medical Center, Rotterdam, The Netherlands.ORCID http://orcid.org/0000-0002-2374-9204
Ian J DearyDepartment of Psychology, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.ORCID http://orcid.org/0000-0002-1733-263X
Sudha SeshadriFramingham Heart Study, Framingham, MA, USA.ORCID http://orcid.org/0000-0001-6135-2622
Katri RäikkönenDepartment of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
University of Helsinki · FIUNSW Sydney · AUUniversity of Edinburgh · GBErasmus MC · NLJohns Hopkins University · USUniversity of Michigan · USBoston University · USQIMR Berghofer Medical Research Institute · AUUniversitätsmedizin Greifswald · DEUniversity of Bonn · DEBrigham and Women's Hospital · USHunter Medical Research Institute · AUIndiana University School of MedicineLeipzig University · DERush University Medical Center · USUniversity of Washington · USBroad Institute · USInstitute of Genetics and Cancer · GBLeiden University Medical Center · NLNational Institutes of Health · US
Funding
HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8MProject 1U19AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI Duygu Tosun-Turgut · 2016 to 2026
$226.7MAlzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0MNational Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)U24AG021886 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI TATIANA M. FOROUD · 2002 to 2026
$119.8MInstitute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8MSUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 1991 to 2020
$49.1MEPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3MResearch Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3MFRAMINGHAM HEART STUDY - YEAR 5 EXAM75N92019D00031 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · 2019 to 2024
$29.8MWomen's Health Study: Continued Follow-upR01CA047988 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., LEE, I-MIN · 1991 to 2014
$28.2MRush Alzheimer's Disease Research CenterP30AG072975 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI Lisa L Barnes, Julie A. Schneider · 2021 to 2026
$24.7MResearch Education ComponentP30AG072976 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDREW J SAYKIN · 2021 to 2026
$24.1MMedical Research Council MC_UU_00007/10NCI NIH HHS R01 CA047988NCI NIH HHS UM1 CA182913NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHGRI NIH HHS U01 HG004424NHGRI NIH HHS U01 HG004446NHGRI NIH HHS U01 HG004729NHLBI NIH HHS 75N92019D00031NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC025195NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL087660NHLBI NIH HHS R01 HL093029NHLBI NIH HHS R01 HL103612NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL119443NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R01 HL122658NHLBI NIH HHS U01 HL054457NHLBI NIH HHS U01 HL054464NHLBI NIH HHS U01 HL054481NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL096917NHLBI NIH HHS U01 HL130114NIAAA NIH HHS K02 AA018755NIAAA NIH HHS R01 AA001455NIAAA NIH HHS R01 AA012502NIAAA NIH HHS R01 AA015416NIA NIH HHS K01 AG049050NIA NIH HHS N01 AG012100NIA NIH HHS P30 AG010133NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066546NIA NIH HHS P30 AG072975NIA NIH HHS P30 AG072976NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG015933NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG019771NIA NIH HHS R01 AG020098NIA NIH HHS R01 AG023629NIA NIH HHS R01 AG032098NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG049607NIA NIH HHS R01 AG054076NIA NIH HHS R03 AG048806NIA NIH HHS R03 AG054936NIA NIH HHS RC2 AG036495NIA NIH HHS RC4 AG039029NIA NIH HHS RF1 AG059421NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG024904NIA NIH HHS U01 AG049505NIA NIH HHS U01 AG052409NIA NIH HHS U01 AG061356NIA NIH HHS U19 AG024904NIA NIH HHS U24 AG021886NINDS NIH HHS R01 NS017950NINDS NIH HHS R01 NS087541NINDS NIH HHS UH2 NS100605NLM NIH HHS R01 LM012535
Abstract
Understanding the genomic basis of memory processes may help in combating neurodegenerative disorders. Hence, we examined the associations of common genetic variants with verbal short-term memory and verbal learning in adults without dementia or stroke (N = 53,637). We identified novel loci in the intronic region of CDH18, and at 13q21 and 3p21.1, as well as an expected signal in the APOE/APOC1/TOMM40 region. These results replicated in an independent sample. Functional and bioinformatic analyses supported many of these loci and further implicated POC1. We showed that polygenic score for verbal learning associated with brain activation in right parieto-occipital region during working memory task. Finally, we showed genetic correlations of these memory traits with several neurocognitive and health outcomes. Our findings suggest a role of several genomic loci in verbal memory processes.
Indexed as
LearningMemory, Short-TermBrainMultifactorial InheritanceVerbal Learning
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