ArticleNature communications2022
Hydrogen-bonded organic framework biomimetic entrapment allowing non-native biocatalytic activity in enzyme.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The trial behind it
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Who cites it
28 citing papers in PubMed.
- Hydrophilic-Stable Nucleoside-Based Hydrogen-Bonded Organic Frameworks (N-HOF) for Therapeutic Bacterial Hybrid Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Potential of Covalent Organic Framework in Pharmacy and Biomedicine: Influence of Structure on Properties and Applications.ChemMedChem · 2026Review
- All-in-One photo-biocatalysis system for sustainable chemical transformations.Nature communications · 2026Article
- An orally administrable hydrogen-bonded organic framework (HOF)-based nanoreactor to reprogram metabolism for senescence intervention.National science review · 2026Article
- Life Cells for future energy systems: adaptation, evolution and exploration.National science review · 2026Review
- Enzyme Immobilization by Hydrogen-Bonded Organic Framework for the Construction of Plant-Wearable Sensor.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Reticular Chemistry: A Versatile Platform for Engineering Heterogenous Biocatalysts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Reticular Frameworks for Advanced Polymer Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Vapor-Assisted Mechanochemical Synthesis of Enzyme and Hydrogen-Bonded Organic Framework Biocomposites.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Optimization of lipase activity in Aspergillus niger C2J6 whole cells using choline chloride ethylene glycol deep eutectic solvent.Scientific reports · 2025Article
- Channel-Directed Enzymatic Depolymerization within a Metal-Organic Framework.ACS applied materials & interfaces · 2025Article
- Design, Synthesis, and Application of Immobilized Enzymes on Artificial Porous Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A Noncationic Biocatalytic Nanobiohybrid Platform for Cytosolic Protein Delivery Through Controlled Perturbation of Intracellular Redox Homeostasis.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Magnetically Responsive Enzyme and Hydrogen-Bonded Organic Framework Biocomposites for Biosensing.Small (Weinheim an der Bergstrasse, Germany) · 2024Article
- Engineering enzyme conformation within liquid-solid hybrid microreactors for enhanced continuous-flow biocatalysis.Nature communications · 2024Article
- Electro-Driven Multi-Enzymatic Cascade Conversion of COAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Boosting the photocatalytic decontamination efficiency using a supramolecular photoenzyme ensemble.Science advances · 2024Article
- Pros and Cons in Various Immobilization Techniques and Carriers for Enzymes.Applied biochemistry and biotechnology · 2024Review
- Flexible hydrogen-bonded organic frameworks (HOFs): opportunities and challenges.Chemical science · 2024Review
- Structural Design and Energy and Environmental Applications of Hydrogen-Bonded Organic Frameworks: A Systematic Review.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nature programs the structural folding of an enzyme that allows its on-demand biofunctionality; however, it is still a long-standing challenge to manually modulate an enzyme's conformation. Here, we design an exogenous hydrogen-bonded organic framework to modulate the conformation of cytochrome c, and hence allow non-native bioactivity for the enzyme. The rigid hydrogen-bonded organic framework, with net-arranged carboxylate inner cage, is in situ installed onto the native cytochrome c. The resultant hydrogen-bonded nano-biointerface changes the conformation to a previously not achieved catalase-like species within the reported cytochrome c-porous organic framework systems. In addition, the preserved hydrogen-bonded organic framework can stabilize the encapsulated enzyme and its channel-like pores also guarantee the free entrance of catalytic substrates. This work describes a conceptual nanotechnology for manoeuvring the flexible conformations of an enzyme, and also highlights the advantages of artificial hydrogen-bonded scaffolds to modulate enzyme activity.
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