Evidence map›Paper›PMID 35973946›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2022

4D Cell-Condensate Bioprinting.

Aixiang Ding, Sang Jin Lee, Rui Tang, Kaelyn L Gasvoda, Felicia He, Eben Alsberg

Erratum issuedAbstract read
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed.

  1. Smart Bioinks for 4D Bioprinting: Requirements, Design, and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  2. Discrete 2D Material Programming for 3D Shaping and Morphogenesis-Inspired 4D Bioprinting.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Multiscale Construction, Evaluation, and Application of Organoids.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Crosslinker-freeMaterials today. Bio · 2025
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Aixiang DingThe Institute of Flexible Electronics (IFE, Future Technologies), Xiamen University, Xiamen, 361005, China.
Sang Jin LeeRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 909 S Wolcott Ave, Chicago, IL, 60612, United States.
Rui TangRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 909 S Wolcott Ave, Chicago, IL, 60612, United States.
Kaelyn L GasvodaRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 909 S Wolcott Ave, Chicago, IL, 60612, United States.
Felicia HeRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 909 S Wolcott Ave, Chicago, IL, 60612, United States.
Eben AlsbergRichard and Loan Hill Department of Biomedical Engineering, University of Illinois at Chicago, 909 S Wolcott Ave, Chicago, IL, 60612, United States.ORCID 0000-0002-3487-4625

Funding

TRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6M
Engineering a Self-assembled, multi-tissue Tracheal ReplacementR01EB023907 · NIBIB · UNIVERSITY OF ILLINOIS AT CHICAGO · PI ALSBERG, EBEN, ROLLE, MARSHA W · 2017 to 2020
$1.9M
Mechanical regulation of endochondral bone regenerationR01AR074948 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI BOERCKEL, JOEL D · 2019 to 2023
$1.7M
NHLBI NIH HHS T32 HL007829NIAMS NIH HHS R01 AR074948NIAMS NIH HHS R01AR074948NIBIB NIH HHS R01 EB023907NIBIB NIH HHS R01EB023907
6 · The paper itself

Abstract

4D bioprinting techniques that facilitate formation of shape-changing scaffold-free cell condensates with prescribed geometries have yet been demonstrated. Here, a simple 4D bioprinting approach is presented that enables formation of a shape-morphing cell condensate-laden bilayer system. The strategy produces scaffold-free cell condensates which morph over time into predefined complex shapes. Cell condensate-laden bilayers with specific geometries are readily fabricated by bioprinting technologies. The bilayers have tunable deformability and microgel (MG) degradation, enabling controllable morphological transformations and on-demand liberation of deformed cell condensates. With this system, large cell condensate-laden constructs with various complex shapes are obtained. As a proof-of-concept study, the formation of the letter "C"- and helix-shaped robust cartilage-like tissues differentiated from human mesenchymal stem cells (hMSCs) is demonstrated. This system brings about a versatile 4D bioprinting platform idea that is anticipated to broaden and facilitate the applications of cell condensation-based 4D bioprinting.

Indexed as

BioprintingMicrogelsCartilageCell DifferentiationHumansHydrogelsPrinting, Three-DimensionalTissue EngineeringTissue ScaffoldsHydrogelsMicrogels4D bioprintingcell aggregateshydrogelsjammed microgelstissue engineering

Identifiers

PMID35973946
PMCPMC9463124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.