Evidence map›Paper›PMID 35973788›Full record

Trial reportClinical and experimental dermatology2022

Regular support provided by dermatological nurses improves outcomes in patients with psoriasis treated with topical drugs: a randomized controlled trial.

Mathias Tiedemann Svendsen, Steven R Feldman, Anna Mejldal, Sören Möller, Line Planck Kongstad, Klaus E Andersen

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Clinical and experimental dermatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04220554 (Long-term Improvement of Psoriasis Patients' Adherence to Topical Drugs), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04220554 nacompletednot on this map

Long-term Improvement of Psoriasis Patients' Adherence to Topical Drugs: Testing a Patient-supporting Intervention Delivered by Healthcare Professionals

TypeinterventionalSponsorOdense University HospitalRan2020 to 2022Enrolled103ConditionsPsoriasis VulgarisArmsImproved support by health-care professionals
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Mathias Tiedemann SvendsenDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-4317-0873
Steven R FeldmanDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.ORCID https://orcid.org/0000-0002-0090-6289
Anna MejldalOpen Patient data Exploratory Network (OPEN), Odense University Hospital, Odense, Denmark.
Sören MöllerDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
Line Planck KongstadDanish Centre for Health Economics (DaCHE), University of Southern Denmark, Odense, Denmark.
Klaus E AndersenDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark.
University of Southern Denmark · DKOdense University Hospital · DK

Funding

Jeweler A.L. Rasmussens Memorial FoundationLEO FondetOdense University Hospital Free Research FundPsoriasis Research FoundationRobert Wehnerts and Kirsten Wehnerts Foundation
6 · The paper itself

Abstract

backgroundPatient adherence to topical antipsoriatic drugs is often poor, leading to poor efficacy. Use of long-term support delivered by dermatological nurses to patients treated with topical drugs may improve outcome.

aimTo evaluate whether regular support from dermatological nurses improves outcome and treatment adherence in patients with psoriasis receiving topical medications.

methodsWe conducted a randomized controlled trial (RCT) (clinicaltrials.gov registration NCT04220554), in which patients received once-daily topical medications (containing corticosteroids and/or calcipotriol) for as long as their psoriasis was visible. The patients were randomly allocated to standard care by the dermatologist either with (n = 51) or without (n = 52) support from dermatological nurses. The nurse support intervention consisted of a structured dermatological consultation at baseline and Week 1, followed by contact with a nurse each month (in the outpatient clinic or by telephone). The primary outcome was severity of psoriasis, which was measured by the Lattice System Physician's Global Assessment (LS-PGA) and assessed by intention-to-treat analyses using linear mixed regression models for longitudinal data. Secondary outcomes were quality of life (measured by the Dermatology Life Quality Index; DLQI) and good adherence (defined as use of ≥ 80% of recommended doses).

resultsIn total, 92 patients (89%) completed the 48-week trial period. The intervention group improved more than the nonintervention group from baseline to Week 24 in LS-PGA (2.21 vs. 1.28, P = 0.001) and in DLQI at Week 12 (6.50 vs. 1.55, P < 0.001). Differences between the two groups in favour of the intervention were observed throughout the study period. More participants in the intervention group had good adherence compared with the nonintervention group (36% vs. 14%, P < 0.001).

conclusionRegular, continued patient support from dermatological nurses increased the efficacy of psoriasis treatment, improved quality of life and enhanced long-term adherence to topical antipsoriatic drugs. However, there is still room for more improvement.

Indexed as

Dermatologic AgentsPsoriasisHumansPatient ComplianceQuality of LifeSeverity of Illness IndexTreatment OutcomeDermatologic Agents

Identifiers

PMID35973788
PMCPMC10092433
OpenAlexW4293869937

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.