ArticleRegional anesthesia and pain medicine2022
Prospective cohort study on the trajectory and association of perioperative anxiety and postoperative opioid-related outcomes.
Article in Regional anesthesia and pain medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06991673 (Adolescent Surgery Roadmap Feasibility and Acceptability Study), which is not on this map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Adolescent Surgery Roadmap Feasibility and Acceptability Study
Who cites it
11 citing papers in PubMed, 20 citations in OpenAlex.
- Green Light Therapy for Pain and Pain-Related Psychosocial Outcomes: A Systematic Review of Human Studies.Journal of clinical medicine · 2026Review
- Preoperative anxiety and chronic postsurgical pain: a signal worth acting on, but clinical translation needs greater nuance.BJA open · 2026Article
- Efficacy of short-term, low-dose oral olanzapine at reducing perioperative anxiety, pain, and enhancing recovery in patients undergoing primary total joint arthroplasty.International journal of surgery (London, England) · 2026Article
- Effects of Intravenous Esketamine or Magnesium Sulfate on Early Postoperative Negative Emotions and Pain in Patients Undergoing Endoscopic Sinus Surgery: A Randomized Controlled Trial.Therapeutics and clinical risk management · 2026Article
- Incidence, Associated Risk Factors, and Outcomes of Postoperative Anxiety in Elderly: A Retrospective Observational Study.Health science reports · 2026Article
- The application of local lesion postoperative continuous irrigation for the perioperative management of spinal tuberculosis with posterior-only approach surgery.Scientific reports · 2025Article
- Prehabilitation Reimagined as Policy: A Multidimensional Framework to Reduce Pain, Opioid Use, and Surgical Risk.International journal of spine surgery · 2025Article
- Preoperative Opioid Misuse Associations With Delayed Opioid Cessation, Pain, and Negative Affect After Spine Surgery.Neurospine · 2025Article
- Factors associated with use of opioid rescue medication after surgery.Regional anesthesia and pain medicine · 2024Observational
- Transitional Pain Service: Optimizing Complex Surgical Patients.Current pain and headache reports · 2024Review
- Comparison of pre and post-operative stresses among Indian patients undergoing intra-oral grafting procedures.Bioinformation · 2023Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
introductionAlthough perioperative anxiety is common, its trajectory and influence on postoperative pain and opioid use are not well understood. We sought to examine the association and trajectory of perioperative anxiety, pain and opioid use following common surgical procedures.
methodsWe conducted a prospective cohort study of 1771 patients undergoing elective surgical procedures. Self-reported opioid use, pain (Brief Pain Inventory) and anxiety (Patient-Reported Outcome Measurement Information System (PROMIS) Anxiety) were recorded on the day of surgery and at 1 month, 3 months and 6 months postsurgery. Clinically significant anxiety was defined as a PROMIS Anxiety T-score ≥55. We examined postoperative opioid use in the context of surgical site pain and anxiety using mixed-effects regression models adjusted for covariates, and examined anxiety as a mediator between pain and opioid use.
resultsIn this cohort, 65% of participants completed all follow-ups and 30% reported clinically significant anxiety at baseline. Anxiety and surgical site pain were highest on the day of surgery (anxiety: mean=49.3, SD=9.0; pain: mean=4.3, SD=3.3) and declined in the follow-up period. Those with anxiety reported higher opioid use (OR=1.40; 95% CI 1.0, 1.9) and 1.14-point increase in patient-reported surgical pain (95% CI 1.0, 1.3) compared with those without anxiety. Anxiety had no significant mediation effect on the relationship of pain and opioid use. DISCUSSION: Anxiety is an independent risk factor for increased pain and opioid use after surgery. Future studies examining targeted behavioral therapies to reduce anxiety during the perioperative period may positively impact postoperative pain and opioid use.
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