Evidence map›Paper›PMID 35973741›Full record

ArticleAmerican journal of perinatology2022

Transfusion Requirements with Hybrid Management of Placenta Accreta Spectrum Incorporating Targeted Embolization and a Selective Use of Delayed Hysterectomy.

Luke A Gatta, Jeremy M Weber, Jennifer B Gilner, Paula S Lee, Chad A Grotegut, Katherine A Herbert, Mustafa Bashir, Carl F Pieper, James Ronald, Waleska Pabon-Ramos and 4 more

Abstract read
In one paragraph

Article in American journal of perinatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luke A GattaDepartment of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina.ORCID 0000-0003-1821-2258
Jeremy M WeberDepartment of Biostatistics and Bioinformatics, Duke University Hospital, Durham, North Carolina.
Jennifer B GilnerDepartment of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina.
Paula S LeeDepartment of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina.
Chad A GrotegutDepartment of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina.
Katherine A HerbertDepartment of Anesthesiology, Duke University Hospital, Durham, North Carolina.
Mustafa BashirDepartment of Radiology and Medicine, Duke University Hospital, Durham, North Carolina.
Carl F PieperDivision of Maternal-Fetal Medicine, Duke University Hospital, Durham, North Carolina.
James RonaldDepartment of Radiology and Medicine, Duke University Hospital, Durham, North Carolina.
Waleska Pabon-RamosDepartment of Radiology and Medicine, Duke University Hospital, Durham, North Carolina.
Ashraf S HabibDepartment of Anesthesiology, Duke University Hospital, Durham, North Carolina.
Kyle C StricklandDepartment of Pathology, Duke University Hospital, Durham, North Carolina.
Angeles Alvarez SecordDepartment of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina.
Andra H JamesDepartment of Obstetrics and Gynecology, Duke University Hospital, Durham, North Carolina.

Funding

Support for QA/QC for Prior Approval ProcessUL1TR002553 · NCATS · DUKE UNIVERSITY · PI LI, JENNIFER S, MCNAMARA, JAMES O. · 2018 to 2023
$58.5M
NCATS NIH HHS UL1 TR002553
6 · The paper itself

Abstract

objectiveThis study compares the number of units of red blood cells (RBCs) transfused in patients with placenta accreta spectrum (PAS) treated with or without a multidisciplinary algorithm that includes placental uterine arterial embolization (P-UAE) and selective use of either immediate or delayed hysterectomy. STUDY

designThis is a retrospective study of deliveries conducted at a tertiary care hospital from 2001 to 2018 with pathology-confirmed PAS. Those with previable pregnancies or microinvasive histology were excluded. To improve the equity of comparison, analyses were made separately among scheduled and unscheduled cases, therefore patients were assigned to one of four cohorts as follows: (1) scheduled/per-algorithm, (2) scheduled/off-algorithm, (3) unscheduled/per-algorithm, or (4) unscheduled/off-algorithm. Primary outcomes included RBCs transfused and estimated blood loss (EBL). Secondary outcomes included perioperative complications and disposition.

resultsOverall, 95 patients were identified, with 87 patients meeting inclusion criteria: 36 treated per-algorithm (30 scheduled and 6 unscheduled) and 51 off-algorithm patients (24 scheduled and 27 unscheduled). Among scheduled deliveries, 9 (30.0%) patients treated per-algorithm received RBCs compared with 20 (83.3%) patients treated off-algorithm (

conclusionA multidisciplinary algorithm including P-UAE and selective use of delayed hysterectomy is associated with a lower rate of blood transfusion in scheduled but not unscheduled cases. KEY POINTS: · An algorithm with delayed hysterectomy had less transfusion in scheduled, but not unscheduled, cases.. · Over time, more cases were managed per algorithm; among scheduled cases, the transfusion rate and volume transfused decreased.. · There were similar transfusion outcomes among off-algorithm cases, regardless if delivery was scheduled..

Indexed as

Placenta AccretaBlood Loss, SurgicalBlood TransfusionCesarean SectionFemaleHumansHysterectomyPlacentaPregnancyRetrospective Studies

Identifiers

PMID35973741
PMCPMC10035416

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.