Evidence map›Paper›PMID 35973606›Full record

ArticleJournal of theoretical biology2022

Understanding the mechanisms of HPV-related carcinogenesis: Implications for cell cycle dynamics.

Derrick T Sund, Andrew F Brouwer, Heather M Walline, Thomas E Carey, Rafael Meza, Trachette Jackson, Marisa C Eisenberg

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of theoretical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Derrick T SundDepartment of Mathematics, University of Michigan, Ann Arbor, MI, United States. Electronic address: dtsund@umich.edu.
Andrew F BrouwerDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, United States.
Heather M WallineDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Thomas E CareyDepartment of Otolaryngology, University of Michigan, Ann Arbor, MI, United States.
Rafael MezaDepartment of Epidemiology, University of Michigan, Ann Arbor, MI, United States.
Trachette JacksonDepartment of Mathematics, University of Michigan, Ann Arbor, MI, United States.
Marisa C EisenbergDepartment of Mathematics, University of Michigan, Ann Arbor, MI, United States; Department of Epidemiology, University of Michigan, Ann Arbor, MI, United States. Electronic address: marisae@umich.edu.
University of Michigan · US

Funding

Mechanistic Modeling of Oropharyngeal Cancer Treatment and Recurrence (Supplement)U01CA182915 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EISENBERG, MARISA C, MEZA, RAFAEL · 2014 to 2019
$3.3M
Molecular Mechanisms of Tumor Behavior and Response to Therapy in HPV-positive Oropharyngeal CancerR01CA194536 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CAREY, THOMAS E. · 2016 to 2021
$2.8M
NCI NIH HHS R01 CA194536NCI NIH HHS U01 CA182915
6 · The paper itself

Abstract

The role of human papillomavirus (HPV) as a causative agent for epithelial cancers is well-known, but many open questions remain regarding the downstream gene regulatory effects of viral proteins E6 and E7 on the cell cycle. Here, we extend a cell cycle model originally presented by Gérard and Goldbeter (2009) in order to capture the effects of E6 and E7 on key actors in the cell cycle. Results suggest that E6 is sufficient to reverse p53-induced quiescence, while E7 is sufficient to reverse p16

Indexed as

AlphapapillomavirusPapillomavirus InfectionsCarcinogenesisCell CycleCell DivisionCyclin-Dependent Kinase Inhibitor p16HumansPapillomaviridaePapillomavirus E7 ProteinsTumor Suppressor Protein p53Cyclin-Dependent Kinase Inhibitor p16Papillomavirus E7 ProteinsTumor Suppressor Protein p53CancerCell cycleHPVMathematical modeling

Identifiers

PMID35973606
PMCPMC9838640
OpenAlexW4291227704

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.