Evidence map›Paper›PMID 35973480›Full record

ArticleExperimental hematology2022

An In Vivo Model for Elucidating the Role of an Erythroid-Specific Isoform of Nuclear Export Protein Exportin 7 (Xpo7) in Murine Erythropoiesis.

Susree Modepalli, Sandra Martinez-Morilla, Srividhya Venkatesan, James Fasano, Katerina Paulsen, Dirk Görlich, Shilpa Hattangadi, Gary M Kupfer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental hematology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Susree ModepalliDepartment of Molecular Oncology, Georgetown University, Washington DC.
Sandra Martinez-MorillaDepartment of Pediatric Hematology-Oncology, Yale School of Medicine, New Haven, CT.
Srividhya VenkatesanDepartment of Pediatric Hematology-Oncology, Yale School of Medicine, New Haven, CT.
James FasanoDepartment of Pediatric Hematology-Oncology, Yale School of Medicine, New Haven, CT.
Katerina PaulsenDepartment of Cellular Logistics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Dirk GörlichDepartment of Cellular Logistics, Max Planck Institute for Biophysical Chemistry, Göttingen, Germany.
Shilpa HattangadiDivision of Kidney, Urologic, and Hematologic Diseases, National Institutes of Health, Bethesda, MD. Electronic address: shilpam.hattangadi@nih.gov.
Gary M KupferDepartment of Molecular Oncology, Georgetown University, Washington DC. Electronic address: Gary.Kupfer@georgetown.edu.
Yale Cancer Center · USGeorgetown University · USMax Planck Institute for Biophysical Chemistry · DENational Institutes of Health · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI Louis M Weiner · 1990 to 2026
$71.5M
Yale Cooperative Hematology Specialized Core CenterU54DK106857 · NIDDK · YALE UNIVERSITY · PI JOHN HWA, Diane S Krause · 2015 to 2026
$9.7M
Novel Mechanisms of Congenital Dyserythropoietic AnemiaR01DK111539 · NIDDK · YALE UNIVERSITY · PI GALLAGHER, PATRICK G · 2020 to 2023
$1.7M
Elucidating the Role of Nuclear Protein Export in Erythroid Nuclear CondensationR01DK102889 · NIDDK · YALE UNIVERSITY · PI HATTANGADI, SHILPA MANOHAR · 2014 to 2017
$1.3M
NCI NIH HHS P30 CA051008NIDDK NIH HHS R01 DK102889NIDDK NIH HHS R01 DK111539NIDDK NIH HHS U54 DK106857
6 · The paper itself

Abstract

Erythroid nuclear condensation is a complex process in which compaction to one-tenth its original size occurs in an active nucleus simultaneously undergoing transcription and cell division. We previously found that the nuclear exportin Exportin7 (Xpo7), which is erythroid- specific and highly induced during terminal erythropoiesis, facilitates nuclear condensation. We also identified a previously unannotated, erythroid-specific isoform of Xpo7 (Xpo7B) containing a novel first exon Xpo7-1b expressed only in late Ter119

Indexed as

ErythropoiesisNuclear ProteinsActive Transport, Cell NucleusAnimalsKaryopherinsMiceProtein Isoformsran GTP-Binding ProteinKaryopherinsNuclear ProteinsProtein Isoformsran GTP-Binding ProteinRanGTP-binding protein 16

Identifiers

PMID35973480
PMCPMC10165728
OpenAlexW4291710901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.