Evidence map›Paper›PMID 35973028›Full record

ArticleScience signaling2022

A BRET Ca

Derrick Cumberbatch, Tetsuya Mori, Jie Yang, Dehui Mi, Paige Vinson, C David Weaver, Carl Hirschie Johnson

Open access · greenAbstract read
In one paragraph

Article in Science signaling, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Derrick CumberbatchDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-9066-0402
Tetsuya MoriDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0001-6036-5261
Jie YangDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-4346-9100
Dehui MiVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0002-8587-2929
Paige VinsonSouthern Research, Birmingham, AL, USA.ORCID 0000-0003-0285-3376
C David WeaverVanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, TN, USA.
Carl Hirschie JohnsonDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, USA.ORCID 0000-0003-2878-3193
Vanderbilt University · USSouthern Research Institute · US

Funding

Fluorescent and Luminescent Kinetic Imaging Plate ReaderS10OD021734 · OD · VANDERBILT UNIVERSITY · PI LINDSLEY, CRAIG · 2016 to 2016
$671k
Coupling Optogenetics with Novel Luminescence Reporters of Neural ActivityR21MH116150 · NIMH · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2018 to 2019
$432k
Novel Luminescence Reporters of Neural Activity Partnered with OptogeneticsR21MH107713 · NIMH · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2015 to 2016
$426k
Coupling Optogenetic Neural Stimulation with Novel Reporters of Synaptic ActivityR21DA034446 · NIDA · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2013 to 2014
$384k
Novel ratiometric luminescence reporters for intracellular free calciumR21MH080035 · NIMH · VANDERBILT UNIVERSITY · PI JOHNSON, CARL HIRSCHIE · 2007 to 2008
$377k
NIDA NIH HHS R21 DA034446NIH HHS S10 OD021734NIMH NIH HHS R21 MH080035NIMH NIH HHS R21 MH107713NIMH NIH HHS R21 MH116150
6 · The paper itself

Abstract

The intrinsic fluorescence of samples confounds the use of fluorescence-based sensors. This is of particular concern in high-throughput screening (HTS) applications using large chemical libraries containing intrinsically fluorescent compounds. To overcome this problem, we developed a bioluminescence resonance energy transfer (BRET) Ca

Indexed as

High-Throughput Screening AssaysSmall Molecule LibrariesEnergy TransferFluorescence Resonance Energy TransferHumansLuminescent MeasurementsSmall Molecule Libraries

Identifiers

PMID35973028
PMCPMC9930640
OpenAlexW4292173924

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.