Evidence map›Paper›PMID 35972982›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Reply to Harwood et al.: Alternative functional conformations of native human α

Daniel Luque, Theodoros Goulas, Carlos P Mata, Soraia R Mendes, F Xavier Gomis-Rüth, José R Castón

Abstract readLetterComment
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Daniel LuqueSpanish National Microbiology Centre, Institute of Health Carlos III, 28220 Madrid, Spain.ORCID 0000-0002-0151-6020
Theodoros GoulasProteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Higher Scientific Research Council (CSIC), Barcelona, 08028 Catalonia, Spain.ORCID 0000-0002-6938-5493
Carlos P MataAstbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds LS2 9JT, United Kingdom.
Soraia R MendesProteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Higher Scientific Research Council (CSIC), Barcelona, 08028 Catalonia, Spain.ORCID 0000-0002-9605-8500
F Xavier Gomis-RüthProteolysis Lab, Department of Structural Biology, Molecular Biology Institute of Barcelona, Higher Scientific Research Council (CSIC), Barcelona, 08028 Catalonia, Spain.ORCID 0000-0002-6848-6874
José R CastónDepartment of Structure of Macromolecules, Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, 28049 Madrid, Spain.ORCID 0000-0003-2350-9048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-MacroglobulinsHumansProtein ConformationA2M protein, humanalpha-Macroglobulins

Identifiers

PMID35972982
PMCPMC9477416

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.