Recent cryogenic electron microscopy structures of human A2M may not be representative of the native protein.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

1. Human α2-Macroglobulin: Architecture, Mechanisms, and Functional Implications.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
   Review
2. Frozen fresh blood plasma preserves the functionality of native human αScientific reports · 2023
   Article
3. Reply to Harwood et al.: Alternative functional conformations of native human αProceedings of the National Academy of Sciences of the United States of America · 2022
   Article

Corrections and comments

• Commented on by
  Reply to Harwood et al.: Alternative functional conformations of native human α2022
• Comment on
  Cryo-EM structures show the mechanistic basis of pan-peptidase inhibition by human α2022

Authors and funding

3 authors at 1 institution in 1 country.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

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