ArticleProceedings of the National Academy of Sciences of the United States of America2022
A flexible and highly sensitive organic electrochemical transistor-based biosensor for continuous and wireless nitric oxide detection.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 66 citations in OpenAlex.
- Multiscale Manufacturing of Organic Electronic Materials.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- State-of-the-Art and Next Generation Intra-Articular Implantable Biosensors for Osteoarthritis: From Analytical Limits to Operational Stability.Biosensors · 2026Review
- Ionic-Bionic Interfaces: Advancing Iontronic Strategies for Bioelectronic Sensing and Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Organic Electrochemical Transistors in Tissue-Interfaced Bioelectronics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- From concept to practice: intra-articular photobiomodulation for knee osteoarthritis.Frontiers in immunology · 2026Review
- Self-Assembly of 3D-Printed Multiscale Micropillar-Based Organic Electrochemical Transistors for Ultrasensitive Dopamine Sensing.ACS nano · 2025Article
- Mechanotransduction-Driven Modulation ofInternational journal of molecular sciences · 2025Article
- Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN).Science advances · 2025Article
- Thermal Processing Creates Water-Stable PEDOT:PSS Films for Bioelectronics.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Additive Manufacturing of Organic Electrochemical Transistors: Methods, Device Architectures, and Emerging Applications.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Employing Triphenylene-Based, Layered, Conductive Metal-Organic Framework Materials as Electrochemical Sensors for Nitric Oxide in Aqueous Media.ACS sensors · 2025Article
- Nitric Oxide in Biomaterial-Based Therapies for Coronary Heart Disease: Mechanistic Insights, Current Advances, and Translational Prospects.Biomaterials research · 2025Review
- Emerging technologies toward the integration of multiple functionalities on non-planar implantable neurophotonics probes.Neurophotonics · 2024Article
- Organic Electrochemical Transistors for Biomarker Detections.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Review
- Electrochemical Detection of Gasotransmitters: Status and Roadmap.ACS sensors · 2024Review
- Complementary integration of organic electrochemical transistors for front-end amplifier circuits of flexible neural implants.Science advances · 2024Article
- Miniaturized Capsule System Toward Real-Time Electrochemical Detection of HAdvanced healthcare materials · 2024Article
- One-Dimensional Implantable Sensors for Accurately Monitoring Physiological and Biochemical Signals.Research (Washington, D.C.) · 2024Review
- Organic Electronics in Biosensing: A Promising Frontier for Medical and Environmental Applications.Biosensors · 2023Review
- New Opportunities of Electrochemistry for Monitoring, Modulating, and Mimicking the Brain Signals.JACS Au · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 9 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As nitric oxide (NO) plays significant roles in a variety of physiological processes, the capability for real-time and accurate detection of NO in live organisms is in great demand. Traditional assessments of NO rely on indirect colorimetric techniques or electrochemical sensors that often comprise rigid constituent materials and can hardly satisfy sensitivity and spatial resolution simultaneously. Here, we report a flexible and highly sensitive biosensor based on organic electrochemical transistors (OECTs) capable of continuous and wireless detection of NO in biological systems. By modifying the geometry of the active channel and the gate electrodes of OECTs, devices achieve optimum signal amplification of NO. The sensor exhibits a low response limit, a wide linear range, high sensitivity, and excellent selectivity, with a miniaturized active sensing region compared with a conventional electrochemical sensor. The device demonstrates continuous detection of the nanomolar range of NO in cultured cells for hours without significant signal drift. Real-time and wireless measurement of NO is accomplished for 8 d in the articular cavity of New Zealand White rabbits with anterior cruciate ligament (ACL) rupture injuries. The observed high level of NO is associated with the onset of osteoarthritis (OA) at the later stage. The proposed device platform could provide critical information for the early diagnosis of chronic diseases and timely medical intervention to optimize therapeutic efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.