Evidence map›Paper›PMID 35972918›Full record

ArticleAmerican journal of respiratory cell and molecular biology2022

Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity.

Li Li, Iain R Konigsberg, Maneesh Bhargava, Sucai Liu, Kristyn MacPhail, Annyce Mayer, Elizabeth J Davidson, Shu-Yi Liao, Zhe Lei, Peggy M Mroz and 3 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Li LiDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Iain R KonigsbergDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine.ORCID 0000-0001-7356-100X
Maneesh BhargavaPulmonary, Allergy, Critical Care and Sleep, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota.ORCID 0000-0002-1294-6181
Sucai LiuDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Kristyn MacPhailDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Annyce MayerDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Elizabeth J DavidsonDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, School of Medicine.
Shu-Yi LiaoDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Zhe LeiDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Peggy M MrozDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
Tasha E FingerlinDepartment of Immunology and Genomic Medicine, National Jewish Health, Denver, Colorado.
Ivana V YangDivision of Pulmonary and Critical Care Sciences.
Lisa A MaierDivision of Environmental and Occupational Health Sciences, Department of Medicine, and.
University of Occupational and Environmental Health Japan · JPCenter for Personalized Cancer Treatment · NLColorado School of Public Health · USNational Jewish Health · USUniversity of Minnesota Medical Center · US

Funding

Colorado Clinical and Translational Sciences InstituteUL1TR001082 · NCATS · UNIVERSITY OF COLORADO DENVER · PI SOKOL, RONALD J. · 2013 to 2017
$48.0M
T Cells in Beryllium Sensitization and DiseaseP01ES011810 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI NEWMAN, LEE S · 2002 to 2013
$14.0M
Predictive Models of Beryllium Sensitization and Chronic Beryllium DiseaseR01ES034767 · NIEHS · NATIONAL JEWISH HEALTH · PI Maneesh Bhargava, Li Li · 2023 to 2026
$3.2M
Using Multi-Omics to Define Regulators and Drivers of Granulomatous Inflammation and Chronic Beryllium DiseaseR01ES033678 · NIEHS · NATIONAL JEWISH HEALTH · PI LISA A MAIER, Ivana V Yang · 2022 to 2026
$3.1M
Exposure in Epigenetic Regulation of Immune Response in CBDR01ES023826 · NIEHS · NATIONAL JEWISH HEALTH · PI MAIER, LISA A, YANG, IVANA V · 2015 to 2019
$2.3M
Colorado Career Development Program in the Genetics and Genomics of Lung DiseasesK12HL090147 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI GERACI, MARK W · 2007 to 2012
$2.0M
The immunoregulatory role of Alveolar Macrophages in Chronic Beryllium DiseaseR01ES025722 · NIEHS · NATIONAL JEWISH HEALTH · PI LI, LI · 2016 to 2020
$1.8M
Functional Genomics Approach to the Role of the JAK/STAT and MAPK Pathway in CBDK01ES020857 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI LI, LI · 2011 to 2013
$382k
NCATS NIH HHS P01ES11810NCATS NIH HHS TL1TR0025331NCATS NIH HHS UL1 TR001082NHLBI NIH HHS K12 HL090147NHLBI NIH HHS K12HL090147NIEHS NIH HHS K01 ES020857NIEHS NIH HHS K01ES020857NIEHS NIH HHS P01 ES011810NIEHS NIH HHS R01 ES023826NIEHS NIH HHS R01ES023826NIEHS NIH HHS R01 ES025722NIEHS NIH HHS R01 ES033678NIEHS NIH HHS R01ES033678NIEHS NIH HHS R01 ES034767
6 · The paper itself

Abstract

Chronic beryllium disease (CBD) is a Th1 granulomatous lung disease preceded by sensitization to beryllium (BeS). We profiled the methylome, transcriptome, and selected proteins in the lung to identify molecular signatures and networks associated with BeS and CBD. BAL cell DNA and RNA were profiled using microarrays from CBD (

Indexed as

BerylliosisAlkanesulfonic AcidsBronchoalveolar LavageBronchoalveolar Lavage FluidChronic DiseaseHumansImmunity, InnateRNAT-LymphocytesAlkanesulfonic AcidsBESRNADNA methylationgene expressionmultiomicsprotein profiling

Identifiers

PMID35972918
PMCPMC9743181
OpenAlexW4291993916

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.