Evidence map›Paper›PMID 35972621›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Prevalence and associated factors of frailty and sarcopenia in multiple system atrophy and progressive supranuclear palsy: a cross-sectional study.

Dan Xie, Hongyan Huang, Quanzhen Zhao, Pingping Ning, Qiuyan Shen, Haitao Lu, Fang Xu, Xia Fu, Yanming Xu

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Sex-related differences in the clinical presentation of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dan XieDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Hongyan HuangDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Quanzhen ZhaoDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Pingping NingDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Qiuyan ShenDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Haitao LuDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Fang XuDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China.
Xia FuOutpatient Department, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China. 154862187@qq.com.
Yanming XuDepartment of Neurology, West China Hospital, Sichuan University, 610041, Chengdu Sichuan, China. neuroxym999@163.com.ORCID http://orcid.org/0000-0002-4172-107X
Sichuan University · CN

Funding

Key Research and Development Program of Sichuan Province 2020YFS0259Miaozi Project in Science and Technology Innovation Program of Sichuan Province 2020JDRC0057
6 · The paper itself

Abstract

objectiveTo investigate the prevalence of, and clinicodemographic factors associated with, frailty and sarcopenia in patients with multiple system atrophy or progressive supranuclear palsy.

methodsA total of 264 participants were recruited in this study. Demographic and clinical data were collected through structured interviews. Frailty was assessed with the clinical frailty scale (CFS), and sarcopenia was assessed with the simple five-item scoring questionnaire (SARC-F).

resultsThe prevalence of frailty and sarcopenia was 48.57% and 35.71% in multiple system atrophy, and 51.09% and 39.13% in progressive supranuclear palsy. Multiple system atrophy patients with frailty or sarcopenia were more likely to be female and have longer disease duration, greater motor impairment, greater non-motor burden, and lower life quality. In multiple system atrophy, frailty was associated with reduced motor function and sarcopenia was associated with female sex, reduced motor function, and orthostatic hypotension. Progressive supranuclear palsy patients with frailty or sarcopenia had more severe motor impairment and non-motor burden, longer disease duration, and lower life quality. In progressive supranuclear palsy, frailty was associated with mentation and gait/midline symptoms, while sarcopenia was associated with reduced daily activity and severe gait/midline symptoms.

conclusionFrailty and sarcopenia may be more common among patients with multiple system atrophy or progressive supranuclear palsy than among the general population, and they are associated with more severe forms of the two diseases. Prospective studies are necessary to clarify causal relationships between frailty/sarcopenia and clinical manifestations of multiple system atrophy and progressive supranuclear palsy.

Indexed as

FrailtyMultiple System AtrophySarcopeniaSupranuclear Palsy, ProgressiveCross-Sectional StudiesFemaleHumansMalePrevalenceProspective StudiesAssociated factorsFrailtyMultiple system atrophyPrevalenceProgressive supranuclear palsySarcopenia

Identifiers

PMID35972621
OpenAlexW4292196910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.