ArticleParasitology research2022
Structure-based in silico design and in vitro acaricidal activity assessment of Acacia nilotica and Psidium guajava extracts against Sarcoptes scabiei var. cuniculi.
Article in Parasitology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- Evaluating Punica granatum mediated AgNPs acaricidal activity against Rhipicephalus microplus and Sarcoptes scabiei using in vitro and in silico analyses.Scientific reports · 2026Article
- Acaricidal Effect of Essential Oils in the Control ofPathogens (Basel, Switzerland) · 2026Article
- Unlocking the Antioxidant, Enzyme Inhibitory and Acaricidal Potential ofFood science & nutrition · 2025Article
- In vitro and in silico study and pharmacokinetic analysis of the acaricidal effectiveness of Cersium arvense extract against Rhipicephalus microplus.Scientific reports · 2025Article
- GCMS analysis and acaricidal activity of Ailanthus altissima extract against cattle tick Rhipicephalus (Boophilus) microplus and Hyalomma anatolicum: in vitro and in silico approach.Scientific reports · 2025Article
- Potential diagnostic and drug target markers in glioblastoma.Scientific reports · 2024Article
- In Silico Exploration and Experimental Validation ofLife (Basel, Switzerland) · 2023Article
- Integrating In Vitro and In Silico Approaches to AssessMolecules (Basel, Switzerland) · 2023Article
- Acaricidal assessment of the fungal extract ofHeliyon · 2023Article
- Article
- In Vitro and In Silico Protocols for the Assessment of Anti-Tick Compounds fromAnimals : an open access journal from MDPI · 2023Article
- Essential Oils againstMolecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infestation by Sarcoptes scabiei var. cuniculi mite causes scabies in humans and mange in animals. Alternative methods for developing environmentally friendly and effective plant-based acaricides are now a priority. The purpose of this research was the in silico design and in vitro evaluation of the efficacy of ethanol extracts of Acacia nilotica and Psidium guajava plant leaves against S. scabiei. Chem-Draw ultra-software (v. 12.0.2.1076.2010) was used to draw 36 distinct compounds from these plants that were employed as ligands in docking tests against S. scabiei Aspartic protease (SsAP). With docking scores of - 6.50993 and - 6.16359, respectively, clionasterol (PubChem CID 457801) and mangiferin (PubChem CID 5281647) from A. nilotica inhibited the targeted protein SsAP, while only beta-sitosterol (PubChem CID 222284) from P. guajava interacted with the SsAP active site with a docking score of - 6.20532. Mortality in contact bioassay at concentrations of 0.25, 0.5, 1.0, and 2.0 g/ml was determined to calculate median lethal time (LT
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