Evidence map›Paper›PMID 35972240›Full record

ArticleApplied and environmental microbiology2022

Evaluation of Multivalent Enterotoxigenic

Hyesuk Seo, Qiangde Duan, Ipshita Upadhyay, Weiping Zhang

Open access · greenAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.0field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hyesuk SeoDepartment of Pathobiology, University of Illinois at Urbana-Champaigngrid.35403.31, Urbana, Illinois, USA.
Qiangde DuanDepartment of Diagnostic Medicine/Pathobiology, Kansas State Universitygrid.36567.31 College of Veterinary Medicine, Manhattan, Kansas, USA.
Ipshita UpadhyayDepartment of Pathobiology, University of Illinois at Urbana-Champaigngrid.35403.31, Urbana, Illinois, USA.
Weiping ZhangDepartment of Pathobiology, University of Illinois at Urbana-Champaigngrid.35403.31, Urbana, Illinois, USA.ORCID 0000-0002-3723-2257
University of Illinois Urbana-Champaign · USKansas State University · US

Funding

Development of MecVax, a Cross Protective Subunit Vaccine for ETECR01AI177144 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI WEIPING ZHANG · 2023 to 2026
$4.6M
A broadly protective subunit vaccine against enterotoxigenic Escherichia coli (ETEC) associateddiarrheaR01AI121067 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI ZHANG, WEIPING · 2016 to 2020
$2.0M
NIAID NIH HHS R01 AI121067NIAID NIH HHS R01 AI177144
6 · The paper itself

Abstract

There are no licensed vaccines against enterotoxigenic Escherichia coli (ETEC), a leading cause of children's diarrhea and travelers' diarrhea. Recently, protein-based vaccine candidate MecVax was demonstrated to induce functional antibodies against both ETEC toxins (heat-stable toxin [STa] and heat-labile toxin [LT]) and seven ETEC adhesins (CFA/I and CS1 to CS6) and to protect against ETEC clinical diarrhea or intestinal colonization preclinically. Those studies used intraperitoneal, intramuscular, and intradermal routes, and a dose range for MecVax protein antigens, toxoid fusion 3xSTa

Indexed as

Bacterial ToxinsEnterotoxigenic Escherichia coliEscherichia coli InfectionsEscherichia coli ProteinsAdhesins, BacterialAnimalsAntibodies, BacterialChildDiarrheaDisease Models, AnimalEnterotoxinsHumansImmunoglobulin GMiceTravelVaccines, CombinedAdhesins, BacterialAntibodies, BacterialBacterial ToxinsEnterotoxinsEscherichia coli ProteinsImmunoglobulin GVaccines, Combineddiarrheadose-dependent effectdose-dependent studyenterotoxigenic Escherichia coliETECMecVaxvaccine

Identifiers

PMID35972240
PMCPMC9469710
OpenAlexW4292062770

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.