Evidence map›Paper›PMID 35972132›Full record

ArticlemSphere2022

The Membrane Activity of the Amphibian Temporin B Peptide Analog TB_KKG6K Sheds Light on the Mechanism That Kills Candida albicans.

Anant Kakar, Luis Enrique Sastré-Velásquez, Michael Hess, László Galgóczy, Csaba Papp, Jeanett Holzknecht, Alessandra Romanelli, Györgyi Váradi, Nermina Malanovic, Florentine Marx

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Synthesis of Ag/TiOScientific reports · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Bactericidal Activity toAntibiotics (Basel, Switzerland) · 2023
    Article
  9. Temporins: Multifunctional Peptides from Frog Skin.International journal of molecular sciences · 2023
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Anant KakarBiocenter, Institute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.
Luis Enrique Sastré-VelásquezBiocenter, Institute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.
Michael HessInstitute for Histology and Embryology, Medical University of Innsbruck, Innsbruck, Austria.
László GalgóczyDepartment of Biotechnology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Csaba PappDepartment of Microbiology, Faculty of Science and Informatics, University of Szeged, Szeged, Hungary.
Jeanett HolzknechtBiocenter, Institute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.
Alessandra RomanelliDepartment of Pharmaceutical Sciences, University of Milan, Milan, Italy.
Györgyi VáradiDepartment of Medical Chemistry, Albert Szent-Györgyi Medical School, University of Szeged, Szeged, Hungary.
Nermina MalanovicInstitute of Molecular Biosciences, Field of Excellence BioHealth, University of Grazgrid.5110.5, Graz, Austria.ORCID 0000-0002-2903-9369
Florentine MarxBiocenter, Institute of Molecular Biology, Medical University of Innsbruck, Innsbruck, Austria.ORCID 0000-0002-8408-1842
Innsbruck Medical University · ATUniversity of Szeged · HUUniversity of Graz · ATUniversity of Milan · IT

Funding

Austrian Science Fund FWF W 1253
6 · The paper itself

Abstract

Temporin B (TB) is a 13-amino-acid-long, cationic peptide secreted by the granular glands of the European frog Rana temporaria. We recently showed that the modified TB peptide analog TB_KKG6K rapidly killed planktonic and sessile Candida albicans at low micromolar concentrations and was neither hemolytic nor cytotoxic to mammalian cells

Indexed as

Antifungal AgentsCandida albicansAmphibiansAnimalsAntimicrobial Cationic PeptidesCardiolipinsFluoresceinsFluorescent DyesIsothiocyanatesPhosphatidylinositolsRanidaeAntifungal AgentsAntimicrobial Cationic PeptidesCardiolipinsFluoresceinsFluorescent DyesIsothiocyanatesPhosphatidylinositolsantifungal peptideCandida albicansdepolarizationleakagemembrane activitypermeabilizationTB analogTemporin Buptake

Identifiers

PMID35972132
PMCPMC9599520
OpenAlexW4292183238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.